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Bo Su
Researcher at Second Military Medical University
Publications - 9
Citations - 381
Bo Su is an academic researcher from Second Military Medical University. The author has contributed to research in topics: Gankyrin & Medicine. The author has an hindex of 6, co-authored 6 publications receiving 329 citations.
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Journal ArticleDOI
p28GANK overexpression accelerates hepatocellular carcinoma invasiveness and metastasis via phosphoinositol 3-kinase/AKT/hypoxia-inducible factor-1α pathways
Jing Fu,Yao Chen,Jie Cao,Tao Luo,You-Wen Qian,Wen Yang,Yibin Ren,Bo Su,Guangwen Cao,Yuan Yang,Yi-Qun Yan,Feng Shen,Meng-Chao Wu,Gen-Sheng Feng,Hongyang Wang +14 more
TL;DR: It is reported that increased expression of p28GANK (Gankyrin, PSMD10, or p28) in human HCC predicts poor survival and disease recurrence after surgery, and the combination of these two parameters is a more powerful predictor of poor prognosis.
Journal ArticleDOI
PSMD10/gankyrin induces autophagy to promote tumor progression through cytoplasmic interaction with ATG7 and nuclear transactivation of ATG7 expression.
Tao Luo,Jing Fu,An Xu,Bo Su,Yibing Ren,Ning Li,Junjie Zhu,Xiaofang Zhao,Rongyang Dai,Jie Cao,Bibo Wang,Wenhao Qin,Jinhua Jiang,Juan Li,Meng-Chao Wu,Gen-Sheng Feng,Yao Chen,Hongyang Wang +17 more
TL;DR: It is reported that PSMD10/gankyrin promotes autophagy in hepatocellular carcinoma (HCC) in response to starvation or stress through 2 complementary routes, and this results present a novel mechanism involving modulation of ATG7 by PS MD10 in sustainingAutophagy, promoting HCC cell survival against starvation or chemotherapy.
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p28GANK Prevents Degradation of Oct4 and Promotes Expansion of Tumor-Initiating Cells in Hepatocarcinogenesis
You-Wen Qian,Yao Chen,Wen Yang,Jing Fu,Jie Cao,Yi Bin Ren,Junjie Zhu,Bo Su,Tao Luo,Xiao–Fang Zhao,Rong–Yang Dai,Juan–Juan Li,Wen Sun,Meng Chao Wu,Gen-Sheng Feng,Hongyang Wang +15 more
TL;DR: In this paper, the authors quantified levels of p28 GANK (Gankyrin), OV6, and Oct4 in 130 human hepatocellular carcinoma (HCC) samples using immunohistochemistry.
Journal ArticleDOI
Interleukin-1β/Iinterleukin-1 receptor-associated kinase 1 inflammatory signaling contributes to persistent Gankyrin activation during hepatocarcinogenesis
Bo Su,Tao Luo,Junjie Zhu,Jing Fu,Xiaofang Zhao,Lei Chen,Hui-Lu Zhang,Yibin Ren,Le-Xing Yu,Xiaojun Yang,Meng-Chao Wu,Gen-Sheng Feng,Shao Li,Yao Chen,Hongyang Wang +14 more
TL;DR: The finding of IL‐1β/IRAK‐1 signaling promoting Gankyrin expression through JNK and NF‐Y/p300/CBP complex provides a fresh view on inflammation‐enhanced hepatocarcinogenesis.
Journal ArticleDOI
High Expression of Proline-Rich Tyrosine Kinase2 is Associated with Poor Survival of Hepatocellular Carcinoma via Regulating Phosphatidylinositol 3-Kinase/AKT Pathway
Jie Cao,Yao Chen,Jing Fu,You-Wen Qian,Yibin Ren,Bo Su,Tao Luo,Rongyang Dai,Liang Huang,Jianjun Yan,Meng-Chao Wu,Yi-Qun Yan,Hongyang Wang +12 more
TL;DR: High PyK2, especially peritumoral Pyk2 was associated with poor survival, disease recurrence, and metastasis in HCC and PI3K-AKT pathway was involved in Pyk1-mediated VEGF expression during HCC progression and invasion.