Wenhao Qin

TL;DR: It is reported that PSMD10/gankyrin promotes autophagy in hepatocellular carcinoma (HCC) in response to starvation or stress through 2 complementary routes, and this results present a novel mechanism involving modulation of ATG7 by PS MD10 in sustainingAutophagy, promoting HCC cell survival against starvation or chemotherapy.

TL;DR: Cholesterol to accumulate in NK cells and activate their effector functions against hepatoma cells against liver tumors in mice with homozygous disruption of ApoE, found.

TL;DR: It is reported that high levels of cholesterol predict good survival and low disease recurrence after surgery and pharmacologically promoting CD44 retention inside lipid rafts obviously attenuated HCC migration and invasion, providing a potential therapeutic strategy to prolong the survival of HCC patients.

TL;DR: It is found that ACADL was frequently downregulated in hepatocellular carcinoma (HCC), and its low expression was significantly correlated with poor clinical prognosis of HCC patients and targeting ACadL/Yap may be a potential strategy for HCC precise treatment.

TL;DR: It is found that IL18 exerted inflammation-dependent tumor-suppressive effects largely by promoting the differentiation, activity, and survival of tumor-infiltrating T cells and differences in the expression of IL18 in tumor tissue versus nontumors were more predictive of patient outcome than overall tissue expression.