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Boris Kysela
Researcher at University of Birmingham
Publications - 27
Citations - 2609
Boris Kysela is an academic researcher from University of Birmingham. The author has contributed to research in topics: DNA ligase & DNA repair. The author has an hindex of 17, co-authored 27 publications receiving 2499 citations. Previous affiliations of Boris Kysela include Aston University & Mount Vernon Hospital.
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Journal ArticleDOI
DNA Ligase IV Mutations Identified in Patients Exhibiting Developmental Delay and Immunodeficiency
Mark O'Driscoll,Karen M. Cerosaletti,Pierre M. Girard,Yan Dai,Markus Stumm,Boris Kysela,Betsy A. Hirsch,Andrew R. Gennery,Susan E. Palmer,J. Seidel,Richard A. Gatti,Raymonda Varon,Marjorie A. Oettinger,Heidemarie Neitzel,Penny A. Jeggo,Patrick Concannon +15 more
TL;DR: Four patients with features including immunodeficiency and developmental and growth delay were found to have mutations in the gene encoding DNA ligase IV (LIG4), and their clinical phenotype closely resembles the DNA damage response disorder, Nijmegen breakage syndrome.
Journal ArticleDOI
Identification of a defect in DNA ligase IV in a radiosensitive leukaemia patient
Enriqueta Riballo,Susan E. Critchlow,Soo Hwang Teo,Aidan J. Doherty,Anne Priestley,Bernard C. Broughton,Boris Kysela,Heather Beamish,Nicholas Plowman,Colin F. Arlett,Alan R. Lehmann,Stephen P. Jackson,Penny A. Jeggo +12 more
TL;DR: It is suggested that a significant defect in NHEJ that leads to pronounced radiosensitivity is compatible with normal human viability and does not cause any major immune dysfunction, however, the defect may confer a predisposition to leukaemia.
Journal ArticleDOI
Identification of a DNA Nonhomologous End-Joining Complex in Bacteria
Geoffrey R. Weller,Boris Kysela,Rajat Roy,Louise M. Tonkin,Elizabeth Scanlan,Marina Della,Susanne Krogh Devine,Jonathan P. Day,Adam Wilkinson,Fabrizio d'Adda di Fagagna,Kevin M. Devine,Richard P. Bowater,Penny A. Jeggo,Stephen P. Jackson,Aidan J. Doherty +14 more
TL;DR: These data provide evidence that many bacteria possess a DNA DSB repair apparatus that shares many features with the NHEJ system of eukarya and suggest that this DNA repair pathway arose before the prokaryotic and eukaryotic lineages diverged.
Journal ArticleDOI
Nonhomologous end joining and V(D)J recombination require an additional factor
Yan Dai,Boris Kysela,L. A. Hanakahi,Kostas G. Manolis,Enriqueta Riballo,Markus Stumm,T. O. Harville,Stephen C. West,Marjorie A. Oettinger,Penny A. Jeggo +9 more
TL;DR: A patient with T−B− severe combined immunodeficiency, whose cells have defects closely resembling those of NHEJ-defective rodent cells, is described, providing strong evidence that additional activities are crucial for N HEJ and V(D)J recombination in mammals.
Journal ArticleDOI
Potential role for 53BP1 in DNA end-joining repair through direct interaction with DNA.
Kuniyoshi Iwabuchi,Balaka P. Basu,Boris Kysela,Takayuki Kurihara,Masao Shibata,Deyu Guan,Yongheng Cao,Tomio Hamada,Kouji Imamura,Penny A. Jeggo,Takayasu Date,Aidan J. Doherty +11 more
TL;DR: It is concluded that p53-binding protein 1 has the potential to participate directly in the repair of DNA double-strand breaks.