Bradley D. Charette

TL;DR: A small-molecule screening platform applied to identify compounds that functionally replace the reprogramming factor Klf4 gave rise to iPS cells that are indistinguishable from murine embryonic stem cells, and can be used to screen large chemical libraries in search of novel compounds to replace theReprogramming factors that induce pluripotency.

TL;DR: The characterization of a small molecule (KHS101) that selectively induces a neuronal differentiation phenotype that accelerates neuronal differentiation by interaction with TACC3 and may provide a basis for pharmacological intervention directed at endogenous NPCs.

TL;DR: In this paper, a small molecule replacement of the Src family of kinases was found to promote the formation of neomycin-resistant iPS cells in the absence of Dox.

TL;DR: A reporter based screen was exploited to identify a new class of compounds that functionally replace Sox2: inhibitors of the Src family of kinases, which provide novel tools to study the molecular mechanism of Sox2 in reprogramming.