Michael Garcia

TL;DR: A small-molecule screening platform applied to identify compounds that functionally replace the reprogramming factor Klf4 gave rise to iPS cells that are indistinguishable from murine embryonic stem cells, and can be used to screen large chemical libraries in search of novel compounds to replace theReprogramming factors that induce pluripotency.

TL;DR: A novel compound “longdaysin” was found to dramatically slow down the speed of the circadian clock through simultaneous inhibition of protein kinases CKIδ, CKIα, and ERK2.

TL;DR: A robotic system, termed the automated compound profiler, capable of both propagating a large number of cell lines in parallel and assaying large collections of molecules simultaneously against a matrix of cellular assays in a highly reproducible manner is described.

TL;DR: In this paper, a small molecule replacement of the Src family of kinases was found to promote the formation of neomycin-resistant iPS cells in the absence of Dox.

TL;DR: The generation of immortalized myoblast cell lines derived from healthy and DM1 patient fibroblasts are described, with MBNL1-containing nuclear foci, mis-splicing events and defective myotube differentiation defects characteristic of DM1 observed.