J
Judith Staerk
Researcher at Oslo University Hospital
Publications - 33
Citations - 6524
Judith Staerk is an academic researcher from Oslo University Hospital. The author has contributed to research in topics: Induced pluripotent stem cell & Embryonic stem cell. The author has an hindex of 21, co-authored 31 publications receiving 6099 citations. Previous affiliations of Judith Staerk include University of Oslo & Ludwig Institute for Cancer Research.
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Journal ArticleDOI
A unique clonal JAK2 mutation leading to constitutive signalling causes polycythaemia vera
Chloé James,Valérie Ugo,Jean-Pierre Le Couedic,Judith Staerk,François Delhommeau,Catherine Lacout,Loïc Garçon,Hana Raslova,Roland Berger,Annelise Bennaceur-Griscelli,Jean-Luc Villeval,Stefan N. Constantinescu,Nicole Casadevall,William Vainchenker +13 more
TL;DR: A clonal and recurrent mutation in the JH2 pseudo-kinase domain of the Janus kinase 2 (JAK2) gene in most (> 80%) polycythaemia vera patients leads to constitutive tyrosine phosphorylation activity that promotes cytokine hypersensitivity and induces erythrocytosis in a mouse model.
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A drug-inducible transgenic system for direct reprogramming of multiple somatic cell types
Marius Wernig,Christopher J. Lengner,Jacob H. Hanna,Michael A. Lodato,Eveline J. Steine,Ruth K. Foreman,Judith Staerk,Styliani Markoulaki,Rudolf Jaenisch +8 more
TL;DR: It is demonstrated that various induction levels of the reprogramming factors can induce pluripotency, the duration of transgene activity directly correlates with reprograming efficiency, and cells from many somatic tissues can be reprogrammed and different cell types require different induction levels.
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Reprogramming of human peripheral blood cells to induced pluripotent stem cells.
Judith Staerk,Meelad M. Dawlaty,Qing Gao,Dorothea Maetzel,Jacob H. Hanna,Cesar Sommer,Gustavo Mostoslavsky,Rudolf Jaenisch +7 more
TL;DR: A polycistronic vector encoding Oct4, Klf4, Sox2 and c-Myc is used to generate iPS cells from from frozen peripheral blood of several donors and these cells were derived from mature T cells as well as myeloid donor cells.
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Reprogramming of murine fibroblasts to induced pluripotent stem cells with chemical complementation of Klf4
Costas A. Lyssiotis,Ruth K. Foreman,Judith Staerk,Michael Garcia,Divya Mathur,Styliani Markoulaki,Jacob H. Hanna,Luke L. Lairson,Bradley D. Charette,Laure C. Bouchez,Michael J. Bollong,Conrad Kunick,Achim Brinker,Charles Y. Cho,Peter G. Schultz,Rudolf Jaenisch +15 more
TL;DR: A small-molecule screening platform applied to identify compounds that functionally replace the reprogramming factor Klf4 gave rise to iPS cells that are indistinguishable from murine embryonic stem cells, and can be used to screen large chemical libraries in search of novel compounds to replace theReprogramming factors that induce pluripotency.
Journal ArticleDOI
Metastable Pluripotent States in NOD-Mouse-Derived ESCs
Jacob H. Hanna,Styliani Markoulaki,Maisam Mitalipova,Albert W. Cheng,John P. Cassady,Judith Staerk,Bryce W. Carey,Christopher J. Lengner,Ruth K. Foreman,Jennifer M. Love,Qing Gao,Jongpil Kim,Rudolf Jaenisch +12 more
TL;DR: It is found that NOD stem cells can be stabilized by providing constitutive expression of Klf4 or c-Myc or small molecules that can replace these factors during in vitro reprogramming, which suggests that stem cells from different genetic backgrounds can assume distinct states of pluripotency in vitro.