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Bradley J. Hintze
Researcher at Duke University
Publications - 18
Citations - 5972
Bradley J. Hintze is an academic researcher from Duke University. The author has contributed to research in topics: Triple-stranded DNA & Base pair. The author has an hindex of 7, co-authored 18 publications receiving 2749 citations. Previous affiliations of Bradley J. Hintze include United States Department of Veterans Affairs & Durham University.
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Journal ArticleDOI
Macromolecular structure determination using X-rays, neutrons and electrons: recent developments in Phenix
Dorothee Liebschner,Pavel V. Afonine,Matthew L. Baker,Gábor Bunkóczi,Vincent B. Chen,Tristan I. Croll,Bradley J. Hintze,Li-Wei Hung,Swati Jain,Airlie J. McCoy,Nigel W. Moriarty,Robert D. Oeffner,Billy K. Poon,Michael G. Prisant,Randy J. Read,Jane S. Richardson,David S. Richardson,Sammito,Oleg V. Sobolev,Duncan H. Stockwell,Thomas C. Terwilliger,Alexandre Urzhumtsev,Alexandre Urzhumtsev,Lizbeth L. Videau,Carmen J. Williams,Paul D. Adams,Paul D. Adams +26 more
TL;DR: Recent developments in the Phenix software package are described in the context of macromolecular structure determination using X-rays, neutrons and electrons.
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MolProbity: More and better reference data for improved all-atom structure validation.
Christopher J. Williams,Jeffrey J. Headd,Nigel W. Moriarty,Michael G. Prisant,Lizbeth L. Videau,Lindsay N. Deis,Vishal Verma,Daniel A. Keedy,Bradley J. Hintze,Vincent B. Chen,Swati Jain,Steven M. Lewis,W. Bryan Arendall,Jack Snoeyink,Paul D. Adams,Simon C. Lovell,Jane S. Richardson,David S. Richardson +17 more
TL;DR: Due to wide application of MolProbity validation and corrections by the research community, in Phenix, and at the worldwide Protein Data Bank, newly deposited structures have continued to improve greatly as measured by Mol probity's unique all‐atom clashscore.
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The crystal structure of Mtr4 reveals a novel arch domain required for rRNA processing.
Ryan N. Jackson,A. Alejandra Klauer,Bradley J. Hintze,Howard Robinson,Ambro van Hoof,Sean J. Johnson +5 more
TL;DR: In vivo and in vitro analyses demonstrate that the Mtr4 arch domain is required for proper 5.8S rRNA processing, and suggest that the arch functions independently of canonical helicase activity.
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Molprobity's ultimate rotamer-library distributions for model validation.
TL;DR: The updated MolProbity rotamer‐library distributions derived from an order‐of‐magnitude larger and more stringently quality‐filtered dataset of about 8000 protein chains are described, and the resulting changes and improvements to model validation as seen by users are explained.
Journal ArticleDOI
New insights into Hoogsteen base pairs in DNA duplexes from a structure-based survey
Huiqing Zhou,Bradley J. Hintze,Isaac J. Kimsey,Bharathwaj Sathyamoorthy,Shan Yang,Jane S. Richardson,Hashim M. Al-Hashimi +6 more
TL;DR: The survey reveals HG preferences similar to those observed for transient HG bps in solution by nuclear magnetic resonance, including stronger preferences for A•T versus G•C bps, TA versus GG steps, and also suggests enrichment at terminal ends with a preference for 5′-purine.