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Branden S. Moriarity
Researcher at University of Minnesota
Publications - 132
Citations - 4873
Branden S. Moriarity is an academic researcher from University of Minnesota. The author has contributed to research in topics: Gene & Biology. The author has an hindex of 26, co-authored 112 publications receiving 3403 citations. Previous affiliations of Branden S. Moriarity include Academy of Sciences of the Czech Republic & Hong Kong Polytechnic University.
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Journal ArticleDOI
PVT1 dependence in cancer with MYC copy-number increase
Yuen-Yi Tseng,Branden S. Moriarity,Wuming Gong,Ryutaro Akiyama,Ashutosh Tiwari,Hiroko Kawakami,Peter Ronning,Brian Reuland,Kacey Guenther,Thomas C. Beadnell,Jaclyn Essig,George Maxwell Otto,M. Gerard O'Sullivan,David A. Largaespada,Kathryn L. Schwertfeger,York Marahrens,Yasuhiko Kawakami,Anindya Bagchi +17 more
TL;DR: Bagchi et al. as mentioned in this paper investigated the role of a nearby long non-coding RNA gene, PVT1, that tends to be co-amplified.
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Human iPSC-Derived Natural Killer Cells Engineered with Chimeric Antigen Receptors Enhance Anti-tumor Activity.
TL;DR: This work has identified a CAR containing the transmembrane domain of NKG2D, the 2B4 co-stimulatory domain, and the CD3ζ signaling domain to mediate strong antigen-specific NK cell signaling that provides standardized, targeted "off-the-shelf" lymphocytes for anti-cancer immunotherapy.
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Phase I trials using Sleeping Beauty to generate CD19-specific CAR T cells
Partow Kebriaei,Harjeet Singh,M. Helen Huls,Matthew J. Figliola,Roland L. Bassett,Simon Olivares,Bipulendu Jena,Margaret J. Dawson,Pappanaicken R. Kumaresan,Shihuang Su,Sourindra Maiti,Jianliang Dai,Branden S. Moriarity,Marie Andrée Forget,Vladimir Senyukov,Aaron F. Orozco,Tingting Liu,Jessica McCarty,Rineka Jackson,Judy S. Moyes,Gabriela Rondon,Muzaffar H. Qazilbash,Stefan O. Ciurea,Amin M. Alousi,Yago Nieto,Katy Rezvani,David Marin,Uday R. Popat,Chitra Hosing,Elizabeth J. Shpall,Hagop M. Kantarjian,Michael J. Keating,William G. Wierda,Kim Anh Do,David A. Largaespada,Dean A. Lee,Dean A. Lee,Perry B. Hackett,Richard E. Champlin,Laurence J.N. Cooper,Laurence J.N. Cooper +40 more
TL;DR: CD19-specific CAR T cells generated with Sleeping Beauty transposon/transposase platforms were safe, and may provide additional cancer control as planned infusions after HSCT, and support further clinical development of this nonviral gene therapy approach.
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EditR: A Method to Quantify Base Editing from Sanger Sequencing.
Mitchell G. Kluesner,Derek A. Nedveck,Walker S. Lahr,John R. Garbe,Juan E. Abrahante,Beau R. Webber,Branden S. Moriarity +6 more
TL;DR: It is demonstrated that EditR is a robust, inexpensive tool that will facilitate the broad application of base editing technology, thereby fostering further innovation in this burgeoning field of gene editing.
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Somatic CRISPR/Cas9-mediated tumour suppressor disruption enables versatile brain tumour modelling.
Marc Zuckermann,Volker Hovestadt,Christiane B. Knobbe-Thomsen,Marc Zapatka,Paul A. Northcott,Kathrin Schramm,Jelena Belic,David T.W. Jones,Barbara R. Tschida,Branden S. Moriarity,David A. Largaespada,Martine F. Roussel,Andrey Korshunov,Guido Reifenberger,Stefan M. Pfister,Peter Lichter,Daisuke Kawauchi,Jan Gronych +17 more
TL;DR: This work has established CRISPR/Cas9-mediated somatic gene disruption, allowing for in vivo targeting of TSGs and demonstrates the utility of this approach by deleting single (Ptch1) or multiple genes in the mouse brain, resulting in the development of medulloblastoma and glioblastomas.