B
Brandon J. Bongers
Researcher at Leiden University
Publications - 9
Citations - 348
Brandon J. Bongers is an academic researcher from Leiden University. The author has contributed to research in topics: Gene & Cancer. The author has an hindex of 4, co-authored 7 publications receiving 204 citations.
Papers
More filters
Journal ArticleDOI
Beyond the hype: deep neural networks outperform established methods using a ChEMBL bioactivity benchmark set
Eelke B. Lenselink,Niels ten Dijke,Brandon J. Bongers,George Papadatos,George Papadatos,Herman W. T. van Vlijmen,Wojtek Kowalczyk,Adriaan P. IJzerman,Gerard J. P. van Westen +8 more
TL;DR: A standardized set to test and evaluate different machine learning algorithms in the context of multi-task learning is offered by providing the data and the protocols.
Journal ArticleDOI
The RESOLUTE consortium: unlocking SLC transporters for drug discovery.
Giulio Superti-Furga,Daniel Lackner,Tabea Wiedmer,Alvaro Ingles-Prieto,Barbara Barbosa,Enrico Girardi,Ulrich Goldmann,Bettina Gürtl,Kristaps Klavins,Christoph Klimek,Sabrina Lindinger,Eva Liñeiro-Retes,André C. Müller,Svenja Onstein,Gregor Redinger,Daniela Reil,Vitaly Sedlyarov,Gernot Wolf,Matthew Crawford,Robert Everley,David Hepworth,Shenping Liu,Stephen Noell,Mary Piotrowski,Robert V. Stanton,Hui Zhang,Salvatore Corallino,Andrea Faedo,Maria Insidioso,Giovanna Maresca,Loredana Redaelli,Francesca Sassone,Lia Scarabottolo,Michela Stucchi,Paola Tarroni,Sara Tremolada,Helena Batoulis,Andreas Becker,Eckhard Bender,Yung-Ning Chang,Alexander Ehrmann,Anke Müller-Fahrnow,Vera Pütter,Diana Zindel,Bradford Hamilton,Martin Lenter,Diana Santacruz,Coralie Viollet,Charles E. Whitehurst,Kai Johnsson,Philipp Leippe,Birgit Baumgarten,Lena Chang,Yvonne Ibig,Martin Pfeifer,Jürgen Reinhardt,Julian Schönbett,Paul Selzer,Klaus Seuwen,Charles Bettembourg,Bruno Biton,Jörg Czech,Hélène de Foucauld,Michel Didier,Thomas Licher,Vincent Mikol,Antje Pommereau,Frédéric Puech,Veeranagouda Yaligara,Aled M. Edwards,Brandon J. Bongers,Laura H. Heitman,Ad P. IJzerman,Huub J. Sijben,Gerard J. P. van Westen,Justine Grixti,Douglas B. Kell,Farah Mughal,Neil Swainston,Marina Wright-Muelas,Tina Bohstedt,N.A. Burgess-Brown,Liz Carpenter,Katharina L. Dürr,Jesper Hansen,Andreea Scacioc,Giulia Banci,Claire Colas,Daniela Digles,Gerhard F. Ecker,Barbara Füzi,Viktoria Gamsjäger,Melanie Grandits,Riccardo Martini,Florentina Troger,Patrick Altermatt,Cédric Doucerain,Franz Dürrenberger,Vania Manolova,Anna-Lena Steck,Hanna Sundström,Maria Wilhelm,Claire M. Steppan +102 more
TL;DR: The Innovative Medicines Initiative Consortium RESOLUTE has started to develop tools and produce data sets to de-orphanize transporters in the solute carrier protein (SLC) superfamily, thereby lowering the barrier for the scientific community to explore SLCs as an attractive drug target class.
Posted ContentDOI
Beyond the Hype: Deep Neural Networks Outperform Established Methods Using A ChEMBL Bioactivity Benchmark Set
Eelke B. Lenselink,Niels ten Dijke,Brandon J. Bongers,George Papadatos,Herman W. T. van Vlijmen,Wojtek Kowalczyk,Adriaan P. IJzerman,Gerard J. P. van Westen +7 more
TL;DR: Here, a standardized set to test and evaluate different machine learning algorithms in the context of multitask learning is offered by providing the data and the protocols.
Journal ArticleDOI
Proteochemometrics - recent developments in bioactivity and selectivity modeling.
TL;DR: The increase in predictive power using proteochemometrics is observed in multi-target bioactivity modeling, opening the door to more extensive studies covering whole protein families.
Journal ArticleDOI
Characterization of cancer-related somatic mutations in the adenosine A2B receptor
Xuesong Wang,Willem Jespers,Brandon J. Bongers,Maria C.C. Habben Jansen,Chantal M. Stangenberger,Majlen A. Dilweg,Hugo Gutiérrez-de-Terán,Adriaan P. IJzerman,Laura H. Heitman,Gerard J. P. van Westen +9 more
TL;DR: This study is the first to investigate the nature of adenosine A2B receptor cancer mutations using a 'single-GPCR-one-G protein' yeast assay technology and may provide insights in mutant receptor function in cancer.