Brett W. Burkhart

TL;DR: A method termed ac 4 C-seq is introduced for the transcriptome-wide mapping of the RNA modification N 4 -acetylcytidine, revealing widespread temperature-dependent acetylation that facilitates thermoadaptation in hyperthermophilic archaea.

TL;DR: It is established that the histone-based mechanism of DNA compaction predates the nucleosome, illuminating the origin of the nucleOSome.

TL;DR: This study reveals conservation of the overall mechanism of ribonucleotide excision repair across domains of life and finds that following RNaseH2 cleavage, the combined activities of polymerase B, flap endonuclease, and DNA ligase are required to complete ribon nucleotide processing.

TL;DR: It is demonstrated here that a fluoride-responsive riboswitch functions to regulate a detoxification pathway in the hyperthermophilic archaeon Thermococcus kodakarensis, defining a universal role for Riboswitch-mediated regulation, and demonstrating the utility of RNA-based regulation at high temperatures.

TL;DR: Deletion of the previously presumed origin region reduced the long-term viability of cultures supporting the possibility that retaining an origin-based mechanism of DNA initiation provides a survival mechanism for stationary phase cells with only one genome.