M
Moran Shalev-Benami
Researcher at Weizmann Institute of Science
Publications - 18
Citations - 926
Moran Shalev-Benami is an academic researcher from Weizmann Institute of Science. The author has contributed to research in topics: Ribosomal RNA & Biology. The author has an hindex of 9, co-authored 13 publications receiving 492 citations. Previous affiliations of Moran Shalev-Benami include Stanford University.
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Journal ArticleDOI
Structure of a Signaling Cannabinoid Receptor 1-G Protein Complex
Kaavya Krishna Kumar,Moran Shalev-Benami,Michael J. Robertson,Hongli Hu,Samuel D. Banister,Scott A. Hollingsworth,Naomi R. Latorraca,Hideaki E. Kato,Daniel Hilger,Shoji Maeda,William I. Weis,William I. Weis,David L. Farrens,Ron O. Dror,Sanjay V. Malhotra,Brian K. Kobilka,Georgios Skiniotis,Georgios Skiniotis +17 more
TL;DR: The structure of the CB1-Gi signaling complex bound to the highly potent agonist MDMB-Fubinaca (FUB) is presented, which compose the structural framework to explain CB1 activation by different classes of ligands and provide insights into the G protein coupling and selectivity mechanisms adopted by the receptor.
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Dynamic RNA acetylation revealed by quantitative cross-evolutionary mapping
Aldema Sas-Chen,Justin M. Thomas,Donna Matzov,Masato Taoka,Kellie D. Nance,Ronit Nir,Keri M Bryson,Ran Shachar,Geraldy L. S. Liman,Brett W. Burkhart,Supuni Thalalla Gamage,Yuko Nobe,Chloe A. Briney,Michaella J. Levy,Ryan T. Fuchs,G. Brett Robb,Jesse Hartmann,Sunny Sharma,Qishan Lin,Laurence Florens,Michael P. Washburn,Toshiaki Isobe,Thomas J. Santangelo,Moran Shalev-Benami,Jordan L. Meier,Schraga Schwartz +25 more
TL;DR: A method termed ac 4 C-seq is introduced for the transcriptome-wide mapping of the RNA modification N 4 -acetylcytidine, revealing widespread temperature-dependent acetylation that facilitates thermoadaptation in hyperthermophilic archaea.
Journal ArticleDOI
Structural Basis for Teneurin Function in Circuit-Wiring: A Toxin Motif at the Synapse.
Jingxian Li,Moran Shalev-Benami,Richard Sando,Xian Jiang,Xian Jiang,Amanuel Kibrom,Jie Wang,Jie Wang,Katherine Leon,Christopher D. Katanski,Olha V. Nazarko,Yue C. Lu,Thomas C. Südhof,Thomas C. Südhof,Georgios Skiniotis,Demet Araç +15 more
TL;DR: The 3.1-Å cryoelectron microscopy structure of the human TEN2 extracellular region (ECR) is reported, revealing a striking similarity to bacterial Tc-toxins and highlighting the unusual structural organization of TENs giving rise to their multifarious functions.
Journal ArticleDOI
2.8-Å Cryo-EM Structure of the Large Ribosomal Subunit from the Eukaryotic Parasite Leishmania
Moran Shalev-Benami,Yan Zhang,Donna Matzov,Y. Halfon,Arie Zackay,Haim Rozenberg,Ella Zimmerman,Anat Bashan,Charles L. Jaffe,Ada Yonath,Georgios Skiniotis +10 more
TL;DR: The 2.8-Å resolution structure of the Leishmania donovani large ribosomal subunit (LSU) derived from a cryo-EM map is presented, further enabling the structural observation of eukaryotic rRNA modifications that play a significant role in ribosome assembly and function.
Journal ArticleDOI
Atomic resolution snapshot of Leishmania ribosome inhibition by the aminoglycoside paromomycin.
Moran Shalev-Benami,Yan Zhang,Haim Rozenberg,Yuko Nobe,Masato Taoka,Donna Matzov,Ella Zimmerman,Anat Bashan,Toshiaki Isobe,Charles L. Jaffe,Ada Yonath,Georgios Skiniotis +11 more
TL;DR: Thecryo-EM structure of the Leishmania ribosome in complex with paromomycin reveals the mechanism by which the drug induces its deleterious effects on the parasite and highlights unique as well as conserved elements in the PAR-binding pocket that can serve as hotspots for the development of novel therapeutics.