Brian Hjelle

TL;DR: Their ubiquity and potential for causing severe human illness make these viruses an important public health concern; the distribution, ecology, disease potential, and genetic spectrum are reviewed.

TL;DR: Two sisters (aged 59 and 46 years) were identified with a disease superficially resembling the myeloneuropathy induced by HTLV-I that may, like HT LV, cause a progressive neurodegenerative disease.

TL;DR: The development of a more streamlined regulatory process world-wide, and the development of pre-competitive knowledge transfer systems such as a global healthcare database focused on regulatory and scientific information for drugs world- Wide are among the ideas proposed to improve the process of academic drug discovery and repurposing and to overcome the "valley of death" by bridging basic to clinical sciences.

TL;DR: These novel viruses may enable the development of small-animal models for HCV, the most common infectious cause of liver failure and hepatocellular carcinoma after hepatitis B virus, and help to explore the health relevance of the highly prevalent human pegiviruses.

TL;DR: Analysis of nuclear DNA from four individuals with familial isolated growth hormone (somatotropin) deficiency (IGHD) type A indicates that this disorder can occur in the presence of variant hGH genes and independent assortment of the two types of h GH genes suggests that these genes are nonallelic.