R
Robert Hromas
Researcher at University of Texas Health Science Center at San Antonio
Publications - 209
Citations - 10725
Robert Hromas is an academic researcher from University of Texas Health Science Center at San Antonio. The author has contributed to research in topics: DNA repair & DNA damage. The author has an hindex of 50, co-authored 196 publications receiving 9622 citations. Previous affiliations of Robert Hromas include University of California, San Diego & University of Iowa.
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Journal ArticleDOI
Transcription factors, normal myeloid development, and leukemia.
TL;DR: In the hematopoietic system, stem cells undergo a process of commitment to multipotential progenitors, which in turn give rise to mature blood cells.
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Cutting edge: IL-17F, a novel cytokine selectively expressed in activated T cells and monocytes, regulates angiogenesis and endothelial cell cytokine production.
Trevor Starnes,Michael J. Robertson,George W. Sledge,Stephanie Kelich,Harikrishna Nakshatri,Hal E. Broxmeyer,Robert Hromas +6 more
TL;DR: Recombinant human IL-17F did not stimulate the proliferation of hematopoietic progenitors or the migration of mature leukocytes, however, it markedly inhibited the angiogenesis of human endothelial cells and induced endotocyte cells to produce IL-2, TGF-β, and monocyte chemoattractant protein-1.
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Cutting edge: IL-17D, a novel member of the IL-17 family, stimulates cytokine production and inhibits hemopoiesis.
TL;DR: A novel cytokine termed IL-17D was cloned using nested RACE PCR and demonstrated an inhibitory effect on hemopoiesis of myeloid progenitor cells in colony formation assays.
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A selective BCL-XL PROTAC degrader achieves safe and potent antitumor activity
Sajid Khan,Xuan Zhang,Dongwen Lv,Qi Zhang,Yonghan He,Peiyi Zhang,Xingui Liu,Dinesh Thummuri,Yaxia Yuan,Janet S. Wiegand,Jing Pei,Weizhou Zhang,Abhisheak Sharma,Christopher R. McCurdy,Vinitha Mary Kuruvilla,Natalia Baran,Adolfo A. Ferrando,Yong-Mi Kim,Anna Rogojina,Peter J. Houghton,Guangcun Huang,Robert Hromas,Marina Konopleva,Guangrong Zheng,Daohong Zhou +24 more
TL;DR: The potential to use PROTAC technology to reduce on-target drug toxicities and rescue the therapeutic potential of previously undruggable targets is demonstrated and DT2216 may be developed as a safe first-in-class anticancer agent targeting BCL-XL.
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Efficient retrovirus-mediated transfer of the multidrug resistance 1 gene into autologous human long-term repopulating hematopoietic stem cells.
Rafat Abonour,David R. Williams,Lawrence H. Einhorn,Kristin M. Hall,Jun Chen,John Coffman,C. M. Traycoff,Arthur Bank,Ikunoshin Kato,Maureen Ward,Stephen D. Williams,Robert Hromas,Michael J. Robertson,Franklin O. Smith,David Woo,Bonnie Mills,Edward F. Srour,Kenneth Cornetta +17 more
TL;DR: Pre-clinical studies indicate that efficient retrovirus-mediated gene transfer into hematopoietic stem cells and progenitor cells can be achieved by co-localizing retroviral particles and target cells on specific adhesion domains of fibronectin.