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Brian Staats
Researcher at Science Applications International Corporation
Publications - 14
Citations - 2673
Brian Staats is an academic researcher from Science Applications International Corporation. The author has contributed to research in topics: Biology & Medicine. The author has an hindex of 7, co-authored 7 publications receiving 2619 citations. Previous affiliations of Brian Staats include National Institutes of Health.
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Journal ArticleDOI
Genome-wide association study of prostate cancer identifies a second risk locus at 8q24
Meredith Yeager,Nick Orr,Richard B. Hayes,Kevin B. Jacobs,Peter Kraft,Sholom Wacholder,Mark J Minichiello,Paul Fearnhead,Kai Yu,Nilanjan Chatterjee,Zhaoming Wang,Zhaoming Wang,Robert W Welch,Robert W Welch,Brian Staats,Brian Staats,Eugenia E. Calle,Heather Spencer Feigelson,Michael J. Thun,Carmen Rodriguez,Demetrius Albanes,Jarmo Virtamo,Stephanie J. Weinstein,Fredrick R. Schumacher,Edward Giovannucci,Walter C. Willett,Geraldine Cancel-Tassin,Olivier Cussenot,Antoine Valeri,Gerald L. Andriole,Edward P. Gelmann,Margaret A. Tucker,Daniela S. Gerhard,Joseph F. Fraumeni,Robert N. Hoover,David J. Hunter,David J. Hunter,Stephen J. Chanock,Gilles Thomas +38 more
TL;DR: Observations indicate the presence of at least two independent loci within 8q24 that contribute to prostate cancer in men of European ancestry, and it is estimated that the population attributable risk of the new locus, marked by rs6983267, is higher than the locus marked byrs1447295.
Journal ArticleDOI
Multiple loci identified in a genome-wide association study of prostate cancer
Gilles Thomas,Kevin B. Jacobs,Meredith Yeager,Meredith Yeager,Peter Kraft,Sholom Wacholder,Nick Orr,Kai Yu,Nilanjan Chatterjee,Robert W Welch,Robert W Welch,Amy Hutchinson,Amy Hutchinson,Andrew Crenshaw,Andrew Crenshaw,Geraldine Cancel-Tassin,Brian Staats,Brian Staats,Zhaoming Wang,Zhaoming Wang,Jesus Gonzalez-Bosquet,Jun Fang,Xiang Deng,Xiang Deng,Sonja I. Berndt,Eugenia E. Calle,Heather Spencer Feigelson,Michael J. Thun,Carmen Rodriguez,Demetrius Albanes,Jarmo Virtamo,Stephanie J. Weinstein,Fredrick R. Schumacher,Edward Giovannucci,Walter C. Willett,Olivier Cussenot,Antoine Valeri,Gerald L. Andriole,E. David Crawford,Margaret A. Tucker,Daniela S. Gerhard,Joseph F. Fraumeni,Robert N. Hoover,Richard B. Hayes,David J. Hunter,David J. Hunter,Stephen J. Chanock +46 more
TL;DR: The findings point to multiple loci with moderate effects associated with susceptibility to prostate cancer that, taken together, in the future may predict high risk in select individuals.
Journal ArticleDOI
SNP500Cancer: a public resource for sequence validation, assay development, and frequency analysis for genetic variation in candidate genes
Bernice Packer,Meredith Yeager,Laura Burdett,Robert Welch,Michael Beerman,Liqun Qi,Hugues Sicotte,Brian Staats,Mekhala Acharya,Andrew Crenshaw,Andrew Eckert,Vinita Puri,Daniela S. Gerhard,Stephen J. Chanock +13 more
TL;DR: The SNP500Cancer database provides sequence and genotype assay information for candidate SNPs useful in mapping complex diseases, such as cancer, and is an invaluable resource for investigators to select SNPs for analysis, design genotyping assays using validated sequence data, choose selected assays already validated on one or more genotypesing platforms, and select reference standards for genotyped assays.
Journal ArticleDOI
SNP500Cancer: a public resource for sequence validation and assay development for genetic variation in candidate genes.
Bernice Packer,Meredith Yeager,Brian Staats,Robert Welch,Andrew Crenshaw,Maureen Kiley,Andrew Eckert,Michael Beerman,Edward Miller,Andrew W. Bergen,Nathaniel Rothman,Robert L. Strausberg,Stephen J. Chanock +12 more
TL;DR: The SNP500Cancer Database provides sequence and genotype assay information for candidate single nucleotide polymorphisms (SNPs) useful in mapping complex diseases, such as cancer.
Journal ArticleDOI
Associations of classic Kaposi sarcoma with common variants in genes that modulate host immunity.
Elizabeth E. Brown,Daniele Fallin,Ingo Ruczinski,Amy Hutchinson,Brian Staats,Francesco Vitale,Carmela Lauria,Diego Serraino,Giovanni Rezza,Georgina Mbisa,Denise Whitby,Angelo Messina,James J. Goedert,Stephen J. Chanock +13 more
TL;DR: Among KSHV-seropositive Italians, CKS risk was associated with diplotypes of IL8RB and IL13, supporting laboratory evidence of immune-mediated pathogenesis, and preliminary evidence for variants in immune-modulating genes that could influence the risk of CKS.