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Amy Hutchinson
Researcher at Science Applications International Corporation
Publications - 62
Citations - 7022
Amy Hutchinson is an academic researcher from Science Applications International Corporation. The author has contributed to research in topics: Single-nucleotide polymorphism & Genome-wide association study. The author has an hindex of 37, co-authored 61 publications receiving 6550 citations. Previous affiliations of Amy Hutchinson include American Cancer Society & Umeå University.
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Journal ArticleDOI
A photoreceptor cell-specific ATP-binding transporter gene (ABCR) is mutated in recessive Stargardt macular dystrophy
Rando Allikmets,Nanda A. Singh,Hui Sun,Noah F. Shroyer,Amy Hutchinson,Abirami Chidambaram,Bernard Gerrard,Lisa Baird,Dora Stauffer,Andy Peiffer,Amir Rattner,Philip M. Smallwood,Yixin Li,Kent L. Anderson,Richard A. Lewis,Jeremy Nathans,Mark Leppert,Michael Dean,James R. Lupski +18 more
TL;DR: Mutational analysis of ABCR in STGD families revealed a total of 19 different mutations including homozygous mutations in two families with consanguineous parentage, indicating that ABCR is the causal gene of STGD/FFM.
Journal ArticleDOI
Mutation of the Stargardt disease gene (ABCR) in age-related macular degeneration
Rando Allikmets,Noah F. Shroyer,Nanda A. Singh,Johanna M. Seddon,Richard A. Lewis,Paul S. Bernstein,Andy Peiffer,Norman A. Zabriskie,Yixin Li,Amy Hutchinson,Michael Dean,James R. Lupski,Mark Leppert +12 more
TL;DR: Identification of ABCR alterations will permit presymptomatic testing of high-risk individuals and may lead to earlier diagnosis of AMD and to new strategies for prevention and therapy.
Journal ArticleDOI
A multi-stage genome-wide association study of bladder cancer identifies multiple susceptibility loci
Nathaniel Rothman,Montserrat Garcia-Closas,Nilanjan Chatterjee,Núria Malats,Xifeng Wu,Jonine D. Figueroa,Francisco X. Real,David Van Den Berg,Giuseppe Matullo,Dalsu Baris,Michael J. Thun,Lambertus A. Kiemeney,Paolo Vineis,Immaculata De Vivo,Demetrius Albanes,Mark P. Purdue,Thorunn Rafnar,Michelle A.T. Hildebrandt,Anne E. Kiltie,Olivier Cussenot,Klaus Golka,Rajesh Kumar,Jack A. Taylor,Jose I. Mayordomo,Kevin B. Jacobs,Manolis Kogevinas,Amy Hutchinson,Zhaoming Wang,Yi-Ping Fu,Ludmila Prokunina-Olsson,Laurie Burdett,Meredith Yeager,William Wheeler,Adonina Tardón,Consol Serra,Alfredo Carrato,Reina García-Closas,Josep Lloreta,Alison Johnson,Molly Schwenn,Margaret R. Karagas,Alan R. Schned,Gerald L. Andriole,Robert L. Grubb,Amanda Black,Eric J. Jacobs,W. Ryan Diver,Susan M. Gapstur,Stephanie J. Weinstein,Jarmo Virtamo,Victoria K. Cortessis,Manuela Gago-Dominguez,Malcolm C. Pike,Malcolm C. Pike,Mariana C. Stern,Jian-Min Yuan,David J. Hunter,Monica McGrath,Colin P.N. Dinney,Bogdan Czerniak,Meng Chen,Hushan Yang,Sita H. Vermeulen,Katja K.H. Aben,J. Alfred Witjes,Remco R. R. Makkinje,Patrick Sulem,Søren Besenbacher,Kari Stefansson,Kari Stefansson,Elio Riboli,Paul Brennan,Salvatore Panico,Carmen Navarro,Naomi E. Allen,H. Bas Bueno-de-Mesquita,Dimitrios Trichopoulos,Dimitrios Trichopoulos,Neil E. Caporaso,Maria Teresa Landi,Federico Canzian,Börje Ljungberg,Anne Tjønneland,Françoise Clavel-Chapelon,D T Bishop,Mark Teo,Margaret A. Knowles,Simonetta Guarrera,Silvia Polidoro,Fulvio Ricceri,Carlotta Sacerdote,Alessandra Allione,Geraldine Cancel-Tassin,Silvia Selinski,Jan G. Hengstler,Holger Dietrich,Tony Fletcher,Peter Rudnai,Eugen Gurzau,Kvetoslava Koppova,Sophia C.E. Bolick,Ashley C. Godfrey,Zongli Xu,José I Sanz-Velez,Maria D. Garcia-Prats,Manuel Sanchez,Gabriel Valdivia,Stefano Porru,Simone Benhamou,Simone Benhamou,Robert N. Hoover,Joseph F. Fraumeni,Debra T. Silverman,Stephen J. Chanock +113 more
TL;DR: Two new regions associated with bladder cancer on chromosomes 22q13.1, 19q12 and 2q37.1 are identified and previous candidate associations for the GSTM1 deletion and a tag SNP for NAT2 acetylation status are validated, and interactions with smoking in both regions are found.
Journal ArticleDOI
Genotype/Phenotype analysis of a photoreceptor-specific ATP-binding cassette transporter gene, ABCR, in Stargardt disease.
Richard A. Lewis,Noah F. Shroyer,Nanda A. Singh,Rando Allikmets,Amy Hutchinson,Yixin Li,James R. Lupski,Mark Leppert,Michael Dean +8 more
TL;DR: Findings support the hypothesis that compound heterozygous ABCR mutations are responsible for STGD1 and that someheterozygousABCR mutations may enhance susceptibility to AMD.
Journal ArticleDOI
Anthropometric measures, body mass index, and pancreatic cancer: a pooled analysis from the Pancreatic Cancer Cohort Consortium (PanScan).
Alan A. Arslan,Kathy J. Helzlsouer,Charles Kooperberg,Xiao-Ou Shu,Emily Steplowski,H. Bas Bueno-de-Mesquita,Charles S. Fuchs,Myron D. Gross,Eric J. Jacobs,Andrea Z. LaCroix,Gloria M. Petersen,Rachael Z. Stolzenberg-Solomon,Wei Zheng,Demetrius Albanes,Laufey T. Amundadottir,William R. Bamlet,Aurelio Barricarte,Sheila Bingham,Heiner Boeing,Marie-Christine Boutron-Ruault,Julie E. Buring,Stephen J. Chanock,Sandra Clipp,J. Michael Gaziano,Edward Giovannucci,Susan E. Hankinson,Patricia Hartge,Robert N. Hoover,David J. Hunter,Amy Hutchinson,Amy Hutchinson,Kevin B. Jacobs,Kevin B. Jacobs,Peter Kraft,Shannon M. Lynch,Jonas Manjer,JoAnn E. Manson,Anne McTiernan,Robert R. McWilliams,Julie B. Mendelsohn,Dominique S. Michaud,Domenico Palli,Thomas E. Rohan,Nadia Slimani,Gilles Thomas,Anne Tjønneland,Geoffrey S. Tobias,Dimitrios Trichopoulos,Dimitrios Trichopoulos,Jarmo Virtamo,Brian M. Wolpin,Kai Yu,Anne Zeleniuch-Jacquotte,Alpa V. Patel +53 more
TL;DR: Findings provide strong support for a positive association between BMI and pancreatic cancer risk and suggest centralized fat distribution may increase pancreatic cancers risk, especially in women.