Brigid Wilson

TL;DR: A point-prevalence study and quasi-experimental intervention from October 28, 2014, through March 31, 2015 was conducted to determine the frequency and sites of contamination on the skin and clothing of personnel during personal protection equipment (PPE) removal and to evaluate the effect of an intervention on the frequency of contamination.

TL;DR: In vitro activity of CAZ-AVI in combination with ATM against diverse Enterobacteriaceae possessing MBLs was demonstrated, and the data presented herein require us to carefully consider this new therapeutic combination to treat infections caused by MBL-producing Enterobacteria.

TL;DR: This review critically examines the clinical performance, advantages, and disadvantages of methods available for the detection of intestinal carriage of CPOs and suggests nucleic acid amplification techniques such as real-time PCR, hybridization assays, loop-mediated isothermal amplification (LAMP), or a combined culture and NAAT approach may provide fast results and/or added sensitivity and specificity compared with culture-based methods.

TL;DR: This work critically evaluates the published literature, identifies relevant clinical trials and review documents submitted to the United States Food and Drug Administration, and discusses ceftazidime/avibactam and imipenem/relebactam, containig a new generation of beta-lactamase inhibitors, which may offer alternatives to treat CRE infections.

TL;DR: Frailty status has a stronger association with inflammation and the inflammatory index than age does among older veterans, and larger studies, in more diverse populations are needed to confirm these findings.