K
Krisztina M. Papp-Wallace
Researcher at Case Western Reserve University
Publications - 102
Citations - 5015
Krisztina M. Papp-Wallace is an academic researcher from Case Western Reserve University. The author has contributed to research in topics: Avibactam & Ceftazidime. The author has an hindex of 35, co-authored 92 publications receiving 3909 citations. Previous affiliations of Krisztina M. Papp-Wallace include United States Department of Veterans Affairs & Veterans Health Administration.
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Journal ArticleDOI
Carbapenems: Past, Present, and Future
Krisztina M. Papp-Wallace,Andrea Endimiani,Andrea Endimiani,Andrea Endimiani,Magdalena A. Taracila,Robert A. Bonomo +5 more
TL;DR: The current “state of the art” of carbapenem antibiotics and their role in the antimicrobial armamentarium are summarized and the medicinal chemist is urged to continue development of these versatile and potent compounds.
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Manganese Transport and the Role of Manganese in Virulence
TL;DR: What is currently known about Mn(2+) transport in proKaryotes and how prokaryotic Mn( 2+) transport is regulated is described and some of the phenotypes that arise when microorganisms lack Mn (2+) are discussed, with an emphasis on those phenotypes involving pathogenesis.
Journal ArticleDOI
New β-Lactamase Inhibitors: a Therapeutic Renaissance in an MDR World
TL;DR: This “renaissance” of β-lactamase inhibitors offers new hope in a world plagued by multidrug-resistant (MDR) Gram-negative bacteria.
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Can Ceftazidime-Avibactam and Aztreonam Overcome β-Lactam Resistance Conferred by Metallo-β-Lactamases in Enterobacteriaceae?
Steven H. Marshall,Andrea M. Hujer,Andrea M. Hujer,Laura J. Rojas,Laura J. Rojas,Krisztina M. Papp-Wallace,Romney M. Humphries,Brad Spellberg,Kristine M. Hujer,Kristine M. Hujer,Emma K. Marshall,Susan D. Rudin,Susan D. Rudin,Federico Perez,Federico Perez,Brigid Wilson,Ronald B. Wasserman,Linda Chikowski,David L. Paterson,Alejandro J. Vila,David van Duin,Barry N. Kreiswirth,Henry F. Chambers,Vance G. Fowler,Michael R. Jacobs,Mark Pulse,William J. Weiss,Robert A. Bonomo +27 more
TL;DR: In vitro activity of CAZ-AVI in combination with ATM against diverse Enterobacteriaceae possessing MBLs was demonstrated, and the data presented herein require us to carefully consider this new therapeutic combination to treat infections caused by MBL-producing Enterobacteria.
Journal ArticleDOI
Inhibitor Resistance in the KPC-2 β-Lactamase, a Preeminent Property of This Class A β-Lactamase
Krisztina M. Papp-Wallace,Christopher R. Bethel,Anne M. Distler,Courtney Kasuboski,Magdalena A. Taracila,Robert A. Bonomo,Robert A. Bonomo +6 more
TL;DR: It is concluded that KPC-2 is unique among class A β-lactamases in being able to readily hydrolyze clavulanic acid, sulbactam, and tazobactam and, by exhibiting unique active site chemistry, may serve as an important scaffold for future development and offer an attractive alternative to the current β- lactamase inhibitors.