J
João H. Duarte
Researcher at National Institute for Medical Research
Publications - 58
Citations - 3351
João H. Duarte is an academic researcher from National Institute for Medical Research. The author has contributed to research in topics: Connective tissue & Immune system. The author has an hindex of 15, co-authored 56 publications receiving 2886 citations. Previous affiliations of João H. Duarte include University of Coimbra & Instituto Gulbenkian de Ciência.
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Journal ArticleDOI
Fate mapping of IL-17-producing T cells in inflammatory responses
Keiji Hirota,João H. Duarte,Marc Veldhoen,Marc Veldhoen,Eve Hornsby,Ying Li,Daniel J. Cua,Helena Ahlfors,Christoph Wilhelm,Mauro Tolaini,Ursula Menzel,Anna Garefalaki,Alexandre J. Potocnik,Brigitta Stockinger +13 more
TL;DR: A reporter mouse strain designed to map the fate of cells that have activated interleukin 17A (IL-17A) allows the actual functional fate of effector T cells to be related to TH17 developmental origin regardless of IL-17 expression.
Journal ArticleDOI
The Aryl Hydrocarbon Receptor: Multitasking in the Immune System
TL;DR: The current understanding of the molecular interactions and functions of AhR in the immune system in steady state and in the presence of infection and inflammation is reviewed, with a focus on barrier organs such as the skin, the gut, and the lung.
Journal ArticleDOI
Plasticity of Th17 cells in Peyer's patches is responsible for the induction of T cell-dependent IgA responses.
Keiji Hirota,Jan-Eric Turner,Matteo Villa,João H. Duarte,Jocelyne Demengeot,Oliver M. Steinmetz,Brigitta Stockinger +6 more
TL;DR: It is found that endogenous cells of the TH17 subset of helper T cells in lymphoid organs of naive mice 'preferentially' homed to the intestines and were maintained independently of IL-23.
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Activation of the aryl hydrocarbon receptor dampens the severity of inflammatory skin conditions.
Paola Di Meglio,João H. Duarte,Helena Ahlfors,Nick D.L. Owens,Ying Li,Federica Villanova,Isabella Tosi,Keiji Hirota,Frank O. Nestle,Ulrich Mrowietz,Michael J. Gilchrist,Brigitta Stockinger +11 more
TL;DR: It is shown that the aryl hydrocarbon receptor (AhR), a transcription factor that senses environmental stimuli, modulates pathology in psoriasis and suggests a critical role for AhR in the regulation of inflammatory responses and opens the possibility for novel therapeutic strategies in chronic inflammatory disorders.
Journal ArticleDOI
Natural Treg cells spontaneously differentiate into pathogenic helper cells in lymphopenic conditions
João H. Duarte,João H. Duarte,Santiago Zelenay,Marie-Louise Bergman,Ana C. Martins,Jocelyne Demengeot +5 more
TL;DR: The findings that Treg convert into pathogenic Th cells in absence of IL‐2 provide new clues to the success of Treg‐based immune therapies.