Mauro Tolaini

TL;DR: A reporter mouse strain designed to map the fate of cells that have activated interleukin 17A (IL-17A) allows the actual functional fate of effector T cells to be related to TH17 developmental origin regardless of IL-17 expression.

TL;DR: Mouse lines expressing Cre recombinase in hematopoietic tissues using the vav regulatory elements, or in lymphoid cells using the hCD2 promoter and locus control region (LCR) are generated, which will be useful in generating tissue‐specific gene deletions within all the cells of hematoplastic or lymphoid tissues.

TL;DR: It was found that during papain-induced lung inflammation, IL-9 production was largely restricted to innate lymphoid cells (ILCs) and was rapidly lost in favor of other cytokines, such as IL-13 and IL-5, which suggested that ILCs provide the missing link between the well-established functions of IL-8 and type 2 helper T cell cytokines and responses.

TL;DR: Human CD2 locus control region (LCR) sequences are shown here to be essential for establishing an open chromatin configuration and that a short region, with no enhancer activity, functions in the establishment, maintenance, or both of an open Chromatin domain.

TL;DR: An improved version of a human CD2 minigene cassette is described, which directs the expression of a reporter mouse CD8 alpha cDNA on all T cells of transgenic mice with an efficiency ten times higher than the previous cassette.