A
Alexandre J. Potocnik
Researcher at University of Edinburgh
Publications - 45
Citations - 4877
Alexandre J. Potocnik is an academic researcher from University of Edinburgh. The author has contributed to research in topics: Antigen & T cell. The author has an hindex of 24, co-authored 45 publications receiving 4295 citations. Previous affiliations of Alexandre J. Potocnik include Max Planck Society & National Institute for Medical Research.
Papers
More filters
Journal ArticleDOI
Fate mapping of IL-17-producing T cells in inflammatory responses
Keiji Hirota,João H. Duarte,Marc Veldhoen,Marc Veldhoen,Eve Hornsby,Ying Li,Daniel J. Cua,Helena Ahlfors,Christoph Wilhelm,Mauro Tolaini,Ursula Menzel,Anna Garefalaki,Alexandre J. Potocnik,Brigitta Stockinger +13 more
TL;DR: A reporter mouse strain designed to map the fate of cells that have activated interleukin 17A (IL-17A) allows the actual functional fate of effector T cells to be related to TH17 developmental origin regardless of IL-17 expression.
Journal ArticleDOI
Transgenic mice with hematopoietic and lymphoid specific expression of Cre.
Jasper de Boer,Adam Williams,George Skavdis,Nicola Harker,Mark Coles,Mauro Tolaini,Trisha Norton,Keith Williams,Kathleen Roderick,Alexandre J. Potocnik,Dimitris Kioussis +10 more
TL;DR: Mouse lines expressing Cre recombinase in hematopoietic tissues using the vav regulatory elements, or in lymphoid cells using the hCD2 promoter and locus control region (LCR) are generated, which will be useful in generating tissue‐specific gene deletions within all the cells of hematoplastic or lymphoid tissues.
Journal ArticleDOI
Fetal and Adult Hematopoietic Stem Cells Require β1 Integrin Function for Colonizing Fetal Liver, Spleen, and Bone Marrow
TL;DR: It is shown that beta1 integrin-deficient HSCs from the para-aortic splanchnopleura and the fetal blood had hematolymphoid differentiation potential in vitro and in fetal organ cultures but were unable to seed fetal and adult hematopoietic tissues.
Journal ArticleDOI
Feedback control of AHR signalling regulates intestinal immunity.
Chris Schiering,Emma Wincent,Amina Metidji,Andrea Iseppon,Ying Li,Alexandre J. Potocnik,Sara Omenetti,Colin J. Henderson,C. Roland Wolf,Daniel W. Nebert,Brigitta Stockinger +10 more
TL;DR: The data indicate that intestinal epithelial cells serve as gatekeepers for the supply of AHR ligands to the host and emphasize the importance of feedback control in modulating AHR pathway activation.
Journal ArticleDOI
Glial cells in the mouse enteric nervous system can undergo neurogenesis in response to injury
Catia Laranjeira,Katarina Sandgren,Nicoletta Kessaris,William D. Richardson,Alexandre J. Potocnik,Pieter Vanden Berghe,Vassilis Pachnis +6 more
TL;DR: It is demonstrated that mouse neural crest cells marked by SRY box-containing gene 10 (Sox10) generate the neuronal and glial lineages of enteric ganglia, and enteric glia maintain limited neurogenic potential, which can be activated by tissue dissociation or injury.