Christoph Wilhelm

TL;DR: It is shown that transforming growth factor-β constitutes a regulatory 'switch' that in combination with other cytokines can 'reprogram' effector T cell differentiation along different pathways.

TL;DR: A reporter mouse strain designed to map the fate of cells that have activated interleukin 17A (IL-17A) allows the actual functional fate of effector T cells to be related to TH17 developmental origin regardless of IL-17 expression.

TL;DR: In this paper, the skin microbiota has an autonomous role in controlling the local inflammatory milieu and tuning resident T lymphocyte function, and skin commensals tuned the function of local T cells in a manner dependent on signaling downstream of the interleukin-1 receptor.

TL;DR: It is shown that the aryl hydrocarbon receptor (AhR) is a crucial regulator in maintaining IEL numbers in both the skin and the intestine, and that AhR deficiency or the lack of AhR ligands compromises the maintenance of IELs and the control of the microbial load and composition.

TL;DR: In mice, the skin microbiota have an autonomous role in controlling the local inflammatory milieu and tuning resident T lymphocyte function and this findings underscore the importance of the microbiota as a distinctive feature of tissue compartmentalization, and provide insight into mechanisms of immune system regulation by resident commensal niches in health and disease.