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Bruna Cerbelli
Researcher at Sapienza University of Rome
Publications - 89
Citations - 1221
Bruna Cerbelli is an academic researcher from Sapienza University of Rome. The author has contributed to research in topics: Medicine & Cancer. The author has an hindex of 14, co-authored 73 publications receiving 662 citations.
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Journal ArticleDOI
Gut metabolomics profiling of non-small cell lung cancer (NSCLC) patients under immunotherapy treatment.
Andrea Botticelli,Andrea Botticelli,Pamela Vernocchi,Federico Marini,Andrea Quagliariello,Bruna Cerbelli,Sofia Reddel,Federica Del Chierico,Francesca Di Pietro,Raffaele Giusti,Alberta Tomassini,Ottavia Giampaoli,Alfredo Miccheli,Ilaria Grazia Zizzari,Marianna Nuti,Lorenza Putignani,Paolo Marchetti,Paolo Marchetti +17 more
TL;DR: The preliminary data suggest a significant role of gut microbiota metabolic pathways in affecting response to immunotherapy, and the metabolic approach could be a promising strategy to contribute to the personalized management of cancer patients by the identification of microbiota-linked “indicators” of early progressor and long responder patients.
Journal ArticleDOI
Can IDO activity predict primary resistance to anti-PD-1 treatment in NSCLC?
Andrea Botticelli,Bruna Cerbelli,Luana Lionetto,Ilaria Grazia Zizzari,Massimiliano Salati,Annalinda Pisano,Mazzuca Federica,Maurizio Simmaco,Marianna Nuti,Paolo Marchetti +9 more
TL;DR: Preliminary results suggest the possibility of using anti-PD-1 plus IDO inhibitor in those patients with high level of kyn/trp ratio, associated with response to immunotherapy, and could predict resistance to anti- PD-1 treatment.
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Impaired mitochondrial biogenesis is a common feature to myocardial hypertrophy and end-stage ischemic heart failure
Annalinda Pisano,Bruna Cerbelli,Elena Perli,Maria Pelullo,V. Bargelli,Carmela Preziuso,Massimiliano Mancini,Langping He,Matthew G.D. Bates,Joaquin R Lucena,Paola Lilla Della Monica,Giuseppe Familiari,Vincenzo Petrozza,Chiara Nediani,Robert W. Taylor,Giulia d'Amati,Carla Giordano +16 more
TL;DR: It is shown that mtDNA depletion is a constant feature of both conditions and characterized also the end-stage phase of cardiomyopathies due to a primary mtDNA defect.
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The sexist behaviour of immune checkpoint inhibitors in cancer therapy
Andrea Botticelli,Concetta Elisa Onesti,Ilaria Grazia Zizzari,Bruna Cerbelli,Paolo Sciattella,Mario Occhipinti,Michela Roberto,Francesca Di Pietro,Adriana Bonifacino,Michele Ghidini,Patrizia Vici,Laura Pizzuti,Chiara Napoletano,Lidia Strigari,Giulia d'Amati,Federica Mazzuca,Marianna Nuti,Paolo Marchetti +17 more
TL;DR: Different mechanisms could be involved in sex differences with regard to immunotherapy and these differences could be relevant to identify immunological targets in order to draw studies exploring novel combinations of immunotherapy agents.
Journal ArticleDOI
Nonischemic left ventricular scar and cardiac sudden death in the young
Cira Di Gioia,Carla Giordano,Bruna Cerbelli,Annalinda Pisano,Elena Perli,Enrico De Dominicis,Barbara Poscolieri,Vincenzo Palmieri,C. Ciallella,Paolo Zeppilli,Giulia d'Amati +10 more
TL;DR: Nonischemic left ventricular scar (NLVS) is a pattern of myocardial injury characterized by midventricular and/or subepicardial gadolinium hyperenhancement at cardiac magnetic resonance, in absence of significant coronary artery disease.