Gut metabolomics profiling of non-small cell lung cancer (NSCLC) patients under immunotherapy treatment.
Andrea Botticelli,Andrea Botticelli,Pamela Vernocchi,Federico Marini,Andrea Quagliariello,Bruna Cerbelli,Sofia Reddel,Federica Del Chierico,Francesca Di Pietro,Raffaele Giusti,Alberta Tomassini,Ottavia Giampaoli,Alfredo Miccheli,Ilaria Grazia Zizzari,Marianna Nuti,Lorenza Putignani,Paolo Marchetti,Paolo Marchetti +17 more
TLDR
The preliminary data suggest a significant role of gut microbiota metabolic pathways in affecting response to immunotherapy, and the metabolic approach could be a promising strategy to contribute to the personalized management of cancer patients by the identification of microbiota-linked “indicators” of early progressor and long responder patients.Abstract:
Despite the efficacy of immune checkpoint inhibitors (ICIs) only the 20–30% of treated patients present long term benefits. The metabolic changes occurring in the gut microbiota metabolome are herein proposed as a factor potentially influencing the response to immunotherapy. The metabolomic profiling of gut microbiota was characterized in 11 patients affected by non-small cell lung cancer (NSCLC) treated with nivolumab in second-line treatment with anti-PD-1 nivolumab. The metabolomics analyses were performed by GC–MS/SPME and 1H-NMR in order to detect volatile and non-volatile metabolites. Metabolomic data were processed by statistical profiling and chemometric analyses. Four out of 11 patients (36%) presented early progression, while the remaining 7 out of 11 (64%) presented disease progression after 12 months. 2-Pentanone (ketone) and tridecane (alkane) were significantly associated with early progression, and on the contrary short chain fatty acids (SCFAs) (i.e., propionate, butyrate), lysine and nicotinic acid were significantly associated with long-term beneficial effects. Our preliminary data suggest a significant role of gut microbiota metabolic pathways in affecting response to immunotherapy. The metabolic approach could be a promising strategy to contribute to the personalized management of cancer patients by the identification of microbiota-linked “indicators” of early progressor and long responder patients.read more
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Oral administration of Akkermansia muciniphila elevates systemic antiaging and anticancer metabolites.
Claudia Grajeda-Iglesias,Sylvère Durand,Sylvère Durand,Sylvère Durand,Romain Daillère,Kristina Iribarren,Fabien Lemaitre,Lisa Derosa,Fanny Aprahamian,Fanny Aprahamian,Fanny Aprahamian,Noélie Bossut,Noélie Bossut,Noélie Bossut,Nitharsshini Nirmalathasan,Nitharsshini Nirmalathasan,Nitharsshini Nirmalathasan,Frank Madeo,Laurence Zitvogel,Guido Kroemer +19 more
TL;DR: Investigating the time-dependent effects of oral administration of Akk and other bacteria to mice on the metabolome of the ileum, colon, liver and blood plasma found that pasteurized Akk (Akk-past) was more efficient than live Akk in elevating the intestinal concentrations of polyamines, short-chain fatty acids, 2-hydroxybutyrate, as well multiple bile acids, which also increased in the circulation.
Journal ArticleDOI
Generation of systemic antitumour immunity via the in situ modulation of the gut microbiome by an orally administered inulin gel
Kai Han,Jutaek Nam,Jin Xu,Xiaoqi Sun,Huang Xuehui,Olamide Animasahun,Abhinav Achreja,Jin Heon Jeon,Benjamin Pursley,Nobuhiko Kamada,Grace Y. Chen,Deepak Nagrath,James J. Moon +12 more
TL;DR: In this article, inulin-a widely consumed dietary fibre-formulated as a 'colon-retentive' orally administered gel can effectively modulate the gut microbiome in situ, induce systemic memory-T-cell responses and amplify the antitumour activity of the checkpoint inhibitor anti-programmed cell death protein-1 (α-PD-1).
Journal ArticleDOI
Gut microbiota-derived short-chain fatty acids and colorectal cancer: Ready for clinical translation?
Huiqin Hou,Danfeng Chen,Kexin Zhang,Wanru Zhang,Tianyu Liu,Sinan Wang,Xin Dai,Bangmao Wang,Weilong Zhong,Hailong Cao +9 more
TL;DR: In this article, the authors summarized the complex crosstalk between short-chain fatty acids and colorectal cancer, which might inspire new approaches for the diagnosis, treatment and prevention of CRC on the basis of gut microbiota-derived metabolites SCFAs.
Journal ArticleDOI
Gut microbiota-derived short-chain fatty acids and colorectal cancer: Ready for clinical translation?
TL;DR: In this article , the authors summarized the complex crosstalk between short-chain fatty acids and colorectal cancer, which might inspire new approaches for the diagnosis, treatment and prevention of CRC on the basis of gut microbiota-derived metabolites SCFAs.
Journal ArticleDOI
Immune System, Microbiota, and Microbial Metabolites: The Unresolved Triad in Colorectal Cancer Microenvironment.
Michelle Hanus,Daniela Parada-Venegas,Glauben Landskron,Ana María Wielandt,Claudia Hurtado,Karin Alvarez,Marcela A. Hermoso,Francisco López-Köstner,Marjorie De la Fuente +8 more
TL;DR: How dynamics in the gut microbiota, their metabolites, and tumor microenvironment interplays in sporadic and hereditary CRC, modulating tumor progression is discussed.
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