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Adam L. Bailey
Researcher at Washington University in St. Louis
Publications - 82
Citations - 5519
Adam L. Bailey is an academic researcher from Washington University in St. Louis. The author has contributed to research in topics: Virus & Simian hemorrhagic fever virus. The author has an hindex of 24, co-authored 76 publications receiving 3101 citations. Previous affiliations of Adam L. Bailey include University of Wisconsin-Madison & National Institutes of Health.
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Journal ArticleDOI
SARS-CoV-2 infection of human ACE2-transgenic mice causes severe lung inflammation and impaired function.
Emma S. Winkler,Adam L. Bailey,Natasha M. Kafai,Sharmila Nair,Broc T. McCune,Jinsheng Yu,Julie M. Fox,Rita E. Chen,James T. Earnest,Shamus P. Keeler,Jon H. Ritter,Liang I. Kang,Sarah Dort,Annette Robichaud,Richard D. Head,Michael J. Holtzman,Michael S. Diamond +16 more
TL;DR: The transgenic mice expressing the human angiotensin I-converting enzyme 2 (ACE2) receptor driven by the cytokeratin-18 (K18) gene promoter are evaluated as a model of SARS-CoV-2 infection to define the basis of lung disease and test immune and antiviral-based countermeasures.
Journal ArticleDOI
Loss of furin cleavage site attenuates SARS-CoV-2 pathogenesis.
Bryan A. Johnson,Xuping Xie,Adam L. Bailey,Birte Kalveram,Kumari G. Lokugamage,Antonio E. Muruato,Jing Zou,Xianwen Zhang,Terry L. Juelich,Jennifer K. Smith,Lihong Zhang,Nathen E. Bopp,Craig Schindewolf,Michelle N Vu,Abigail Vanderheiden,Emma S. Winkler,Daniele M. Swetnam,Jessica A. Plante,Patricia V. Aguilar,Kenneth S. Plante,Vsevolod L. Popov,Benhur Lee,Scott C. Weaver,Mehul S. Suthar,Andrew Routh,Ping Ren,Zhiqiang Ku,Zhiqiang An,Kari Debbink,Michael S. Diamond,Pei Yong Shi,Alexander N. Freiberg,Vineet D. Menachery +32 more
TL;DR: In this paper, a mutant SARS-CoV-2 that lacks the furin cleavage site (ΔPRRA) was generated, which had faster kinetics, improved fitness in Vero E6 cells and reduced spike protein processing.
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A SARS-CoV-2 Infection Model in Mice Demonstrates Protection by Neutralizing Antibodies.
Ahmed O. Hassan,James Brett Case,Emma S. Winkler,Larissa B. Thackray,Natasha M. Kafai,Adam L. Bailey,Broc T. McCune,Julie M. Fox,Rita E. Chen,Wafaa B. Alsoussi,Jackson S. Turner,Aaron J. Schmitz,Tingting Lei,Swathi Shrihari,Shamus P. Keeler,Daved H. Fremont,Suellen Greco,Paul B. McCray,Stanley Perlman,Michael J. Holtzman,Ali H. Ellebedy,Michael S. Diamond +21 more
TL;DR: Transduced replication-defective adenoviruses encoding human ACE2 via intranasal administration into BALB/c mice and established receptor expression in lung tissues and passive transfer of a neutralizing monoclonal antibody reduced viral burden in the lung and mitigated inflammation and weight loss.
Journal ArticleDOI
Hemagglutinin Receptor Binding Avidity Drives Influenza A Virus Antigenic Drift
Scott E. Hensley,Suman R. Das,Adam L. Bailey,Loren M. Schmidt,Heather D. Hickman,Akila Jayaraman,Karthik Viswanathan,Rahul Raman,Ram Sasisekharan,Jack R. Bennink,Jonathan W. Yewdell +10 more
TL;DR: It is proposed that in response to variation in neutralizing antibody pressure between individuals, influenza A virus evolves by adjusting receptor binding avidity via amino acid substitutions throughout the hemagglutinin globular domain, many of which simultaneously alter antigenicity.
Journal ArticleDOI
A Single-Dose Intranasal ChAd Vaccine Protects Upper and Lower Respiratory Tracts against SARS-CoV-2.
Ahmed O. Hassan,Natasha M. Kafai,Igor P. Dmitriev,Julie M. Fox,Brittany K. Smith,Ian B. Harvey,Rita E. Chen,Emma S. Winkler,Alex W. Wessel,James Brett Case,Elena A. Kashentseva,Broc T. McCune,Adam L. Bailey,Haiyan Zhao,Laura A. VanBlargan,Ya Nan Dai,Meisheng Ma,Lucas J. Adams,Swathi Shrihari,Jonathan E. Danis,Lisa E. Gralinski,Yixuan J. Hou,Alexandra Schäfer,Arthur S. Kim,Shamus P. Keeler,Daniela Weiskopf,Ralph S. Baric,Michael J. Holtzman,Daved H. Fremont,David T. Curiel,Michael S. Diamond +30 more
TL;DR: Intranasal administration of a chimpanzee adenovirus-vectored vaccine encoding a pre-fusion stabilized spike protein is a candidate for preventing SARS-CoV-2 infection and transmission, and curtailing pandemic spread.