Bulmaro Cisneros

TL;DR: The historical background of Dp71 and the experimental models developed for its study are described and experimental evidence supporting the participation of D p71 in different cellular processes, including cell adhesion, water homeostasis, cell division, and nuclear architecture is presented.

TL;DR: Based on previous experience with other polyglutamine disorders and considering the molecular basis of SCA2 pathogenesis, a nuclei-acid-based strategy focused on the specific silencing of the dominant disease allele that preserves the expression of the wild-type allele is highly desirable and might prevent toxic neurodegenerative sequelae.

TL;DR: The association of members of the nuclear DAPC with the nuclear matrix indicates that they may work as scaffolding proteins involved in nuclear architecture.

TL;DR: A novel connection between physiological phenotypes and synaptic protein dysregulation, indicative of synaptic dysfunction in myotonic dystrophy type 1 brain pathology is found.

TL;DR: Examination of changes in gene expression in two human cell lines, HepG2 and A549, induced by exposure to a soil extract containing PAH using microarry technology confirmed most of the microarray data with significant correlation.