Byung-Wook Park

TL;DR: The promises and challenges of employing bioengineered bacteria in drug delivery systems are reviewed, the biohybrid design concept is introduced as a new additional paradigm in bacteria-based drug delivery and the design of unique, complex therapeutic functions are introduced.

TL;DR: The results reveal the feasibility of using these active multifunctional bacteria-driven microswimmers to perform targeted drug delivery with significantly enhanced drug transfer, when compared with the passive PEM microparticles.

TL;DR: It is demonstrated here that the nonpathogenic magnetotactic bacteria Magnetosopirrillum gryphiswalense (MSR-1) can be integrated with drug-loaded mesoporous silica microtubes to build controllable microswimmers (biohybrids) capable of antibiotic delivery to target an infectious biofilm.

TL;DR: This in vitro model demonstrates the proof-of-concept feasibility of the proposed soft microswimmers and offers promise for potential biomedical applications in active and/or targeted transport and delivery of imaging agents, drugs, stem cells, siRNA, and therapeutic genes to live tissue in in vitro disease models and stagnant or low-flow-velocity fluidic regions of the human body.

TL;DR: The multifunctional microtubular swimmers present a new generation of biocompatible micromotors toward future microbiorobots and minimally invasive medical applications.