C. Shad Thaxton

TL;DR: An ultrasensitive method for detecting protein analytes has been developed and comparable clinically accepted conventional assays for detecting the same target have sensitivity limits of ∼3 picomdar, six orders of magnitude less sensitive than what is observed with this method.

TL;DR: By chemically tailoring the density of DNA bound to the surface of gold nanoparticles, a tunable gene knockdown was demonstrated and it was demonstrated that gold nanoparticle-oligonucleotide complexes are nontoxic to the cells under the conditions studied.

TL;DR: The recently developed ultrasensitive bio-barcode assay was used to measure the concentration of amyloid-beta-derived diffusible ligands (ADDLs), a potential soluble pathogenic Alzheimer's disease marker, in the cerebrospinal fluid of 30 individuals.

TL;DR: This paper demonstrates how one can chemically design Raman dye-functionalized nanoparticle probes with specific protein-binding affinities and use these probes, coupled with surface-enhanced Raman scattering (SERS) spectroscopy, to perform multiplexed screening of protein-small molecule interactions and protein-protein interactions in a protein microarray format.

TL;DR: A previously undescribed gold nanoparticle bio-barcode assay probe for the detection of prostate specific antigen (PSA) at 330 fg/mL, automation of the assay, and the results of a clinical pilot study designed to assess the ability to detect PSA in the serum of 18 men who have undergone radical prostatectomy for prostate cancer are reported.