C
C. Wayne Smith
Researcher at Baylor College of Medicine
Publications - 174
Citations - 13957
C. Wayne Smith is an academic researcher from Baylor College of Medicine. The author has contributed to research in topics: Inflammation & Integrin. The author has an hindex of 56, co-authored 174 publications receiving 13256 citations. Previous affiliations of C. Wayne Smith include University of Virginia & Agricultural Research Service.
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Journal ArticleDOI
The inflammatory response in myocardial infarction
TL;DR: This review summarizes the current understanding of the cellular and molecular mechanisms regulating the inflammatory response following myocardial ischemia and reperfusion and concludes that by promoting more effective tissue repair, it may be possible to reduce the deleterious remodeling.
Journal ArticleDOI
ELAM-1 is an adhesion molecule for skin-homing T cells
Louis J. Picker,Louis J. Picker,Louis J. Picker,Takashi Kei Kishimoto,Takashi Kei Kishimoto,C. Wayne Smith,R. Aaron Warnock,R. Aaron Warnock,Eugene C. Butcher,Eugene C. Butcher +9 more
TL;DR: It is concluded that at sites of chronic inflammation, ELAM-1 may function as a skin vascular addressin, a tissue-selective endothelial cell-adhesion molecule for skin-homing memory T lymphocytes.
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T-cell accumulation and regulated on activation, normal T cell expressed and secreted upregulation in adipose tissue in obesity.
Huaizhu Wu,Sudip Ghosh,Sudip Ghosh,Xiaoyuan Dai Perrard,Lili Feng,Gabriela Garcia,Jerry L. Perrard,John F. Sweeney,Leif E. Peterson,Lawrence Chan,C. Wayne Smith,Christie M. Ballantyne,Christie M. Ballantyne +12 more
TL;DR: Obesity is associated with increased accumulation of T cells and macrophages in AT, which may play important roles in obesity-related disease by influencing preadipocytes/adipocyte functions.
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Resident Cardiac Mast Cells Degranulate and Release Preformed TNF-α, Initiating the Cytokine Cascade in Experimental Canine Myocardial Ischemia/Reperfusion
Nikolaos G. Frangogiannis,Merry L. Lindsey,Lloyd H. Michael,Keith A. Youker,Robert B. Bressler,Leonardo H. Mendoza,Robert N. Spengler,C. Wayne Smith,Mark L. Entman +8 more
TL;DR: It is suggested that mast cell-derived TNF-alpha may be a crucial factor in upregulating IL-6 in infiltrating leukocytes and initiating the cytokine cascade responsible for myocyte ICAM-1 induction and subsequent neutrophil-induced injury.
Journal ArticleDOI
Spontaneous Skin Ulceration and Defective T Cell Function in CD18 Null Mice
Karin Scharffetter-Kochanek,Karin Scharffetter-Kochanek,Huifang Lu,Keith E. Norman,Nicole van Nood,Flor M. Munoz,Stephan Grabbe,Mark J. McArthur,Isabel Lorenzo,Isabel Lorenzo,Sheldon L. Kaplan,Klaus Ley,C. Wayne Smith,Charles A. Montgomery,Susan Solliday Rich,Arthur L. Beaudet,Arthur L. Beaudet +16 more
TL;DR: A severe defect in T cell proliferation was found in the CD18 null mice when T cell receptors were stimulated either by staphylococcal enterotoxin A or by major histocompatibility complex alloantigens demonstrating a greater role of CD11/CD18 integrins in Tcell responses than previously documented.