C Wooding

TL;DR: Investigation of multiple endocrine neoplasia type 1 patients found that parathyroid tumours were the first manifestation of MEN1 in 87% of patients, and amongst the pituitary and pancreatic tumours, somatotrophinomas and gastrinomas were more common in patients above the age of 40 years, whilst insulinomas occurred more frequently in patients below the ageof 40 years.

TL;DR: The results provide the basis for a molecular-genetic screening approach that will supplement the clinical evaluation and genetic counseling of members of MEN1 families and SSCP was found to be a sensitive and specific mutational screening method that detected >85% of the mutations.

TL;DR: The single-stranded conformational polymorphism identification of CaR mutations may help in the distinction of FBH from mild primary hyperparathyroidism which can be clinically difficult.

TL;DR: It is concluded that a single inherited locus on chromosome 11, band q13, causesMEN-1 and that the monoclonal development of parathyroid and pancreatic tumors in patients with MEN-1 involves similar allelic deletions on chromosomes 11.

TL;DR: It is suggested that ATP binding, not hydrolysis, drives the major conformational change associated with solute translocation in P‐glycoprotein, and biochemical data suggest that these rearrangements may involve rotation of transmembrane α‐helices.