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Stephen M Shalet

Researcher at National Health Service

Publications -  395
Citations -  26577

Stephen M Shalet is an academic researcher from National Health Service. The author has contributed to research in topics: Growth hormone deficiency & Growth hormone secretion. The author has an hindex of 88, co-authored 394 publications receiving 25635 citations. Previous affiliations of Stephen M Shalet include Boston Children's Hospital.

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Insulin-like growth factor (IGF)-I, IGF binding protein-3, and cancer risk: systematic review and meta-regression analysis

TL;DR: Circulating concentrations of IGF-I and IGFBP-3 are associated with an increased risk of common cancers, but associations are modest and vary between sites.
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Consensus guidelines for the diagnosis and treatment of growth hormone (GH) deficiency in childhood and adolescence: Summary statement of the GH research society

Kenneth M. Attie, +43 more
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Clinical studies of multiple endocrine neoplasia type 1 (MEN1)

TL;DR: Investigation of multiple endocrine neoplasia type 1 patients found that parathyroid tumours were the first manifestation of MEN1 in 87% of patients, and amongst the pituitary and pancreatic tumours, somatotrophinomas and gastrinomas were more common in patients above the age of 40 years, whilst insulinomas occurred more frequently in patients below the ageof 40 years.
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Spermatogenesis After Cancer Treatment: Damage and Recovery

TL;DR: The vast majority of men receiving procarbazine-containing regimens for the treatment of lymphomas are rendered permanently infertile, whereas treatment with doxorubicin hydrochloride (Adriamycin), bleomycin, vinblastine, and dacarbazine appears to have a significant advantage, with a return to normal fertility in the vastmajority of patients.
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Hypopituitarism following external radiotherapy for pituitary tumours in adults.

TL;DR: There is a high incidence of anterior pituitary hormone deficiencies in patients treated surgically forpituitary tumours and the incidence increases after external radiotherapy and endocrine testing is recommended on an annual basis.