C
Caitriona M. O'Driscoll
Researcher at University College Cork
Publications - 135
Citations - 5926
Caitriona M. O'Driscoll is an academic researcher from University College Cork. The author has contributed to research in topics: Gene delivery & Small interfering RNA. The author has an hindex of 38, co-authored 124 publications receiving 4860 citations. Previous affiliations of Caitriona M. O'Driscoll include University College Dublin & Trinity College, Dublin.
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Journal ArticleDOI
Lipid-based formulations for intestinal lymphatic delivery.
TL;DR: The success and limitations of a formulation approach using lipid-based vehicles are analyzed, potential areas for further research are highlighted and a deeper appreciation of all the mechanisms is still unrealized.
Journal ArticleDOI
Biopharmaceutical challenges associated with drugs with low aqueous solubility--the potential impact of lipid-based formulations.
TL;DR: The need for more examples of in vitro-in vivo correlations as a means of maximizing the development potential and commercial future for lipid-based formulations, and, promoting confidence within the industry for these delivery systems is highlighted.
Journal ArticleDOI
PEGylated gold nanoparticles: polymer quantification as a function of PEG lengths and nanoparticle dimensions
Kamil Rahme,Kamil Rahme,Kamil Rahme,Lan Chen,Lan Chen,Lan Chen,Richard G. Hobbs,Richard G. Hobbs,Michael A. Morris,Michael A. Morris,Caitriona M. O'Driscoll,Justin D. Holmes,Justin D. Holmes +12 more
TL;DR: In this paper, the authors showed that the overall mean diameter and zeta potential of the capped nanoparticles increased in a non-linear way with increasing molecular weight of the thiolated polyethylene glycol (mPEG-SH) ligand.
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Comparison of drug transporter gene expression and functionality in Caco-2 cells from 10 different laboratories.
Rose Hayeshi,Constanze Hilgendorf,Per Artursson,Patrick Augustijns,Birger Brodin,Pascale Dehertogh,Karen A. Fisher,Lina Fossati,Egbert Hovenkamp,Timo Korjamo,C. Masungi,Nathalie Maubon,Raf Mols,Anette Müllertz,Jukka Mönkkönen,Caitriona M. O'Driscoll,H.M. Oppers-Tiemissen,Eva G E Ragnarsson,Martijn Rooseboom,Anna-Lena Ungell +19 more
TL;DR: absolute expression of genes was variable indicating that small differences in culture conditions have a significant impact on gene expression, although the overall expression patterns were similar, andeterogeneity in transporter activity may be due to differences in transporter expression.
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Lipid-based nanocarriers for oral peptide delivery.
Zhigao Niu,Inmaculada Conejos-Sánchez,Brendan T. Griffin,Caitriona M. O'Driscoll,María J. Alonso +4 more
TL;DR: The lipid-based nanostructures designed so far for the oral administration of peptides and proteins are overviewed and the influence of their composition and physicochemical and pharmaceutical properties, on their interaction with the gastro-intestinal environment, and the subsequent PK/PD profile of the associated drugs is analyzed.