C
Caixia Ma
Researcher at University of British Columbia
Publications - 38
Citations - 3169
Caixia Ma is an academic researcher from University of British Columbia. The author has contributed to research in topics: Citrobacter rodentium & Colitis. The author has an hindex of 21, co-authored 36 publications receiving 2727 citations. Previous affiliations of Caixia Ma include Family Research Institute & Boston Children's Hospital.
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Journal ArticleDOI
Muc2 Protects against Lethal Infectious Colitis by Disassociating Pathogenic and Commensal Bacteria from the Colonic Mucosa
Kirk Bergstrom,Vanessa Kissoon-Singh,Deanna L. Gibson,Caixia Ma,Marinieve Montero,Ho Pan Sham,Natasha R. Ryz,Tina Huang,Anna Velcich,B. Brett Finlay,Kris Chadee,Bruce A. Vallance +11 more
TL;DR: Muc2 production is critical for host protection during A/E bacterial infections, by limiting overall pathogen and commensal numbers associated with the colonic mucosal surface and limiting tissue damage and translocation of pathogenic and Commensal bacteria across the epithelium.
Journal ArticleDOI
Noncanonical inflammasome activation of caspase-4/caspase-11 mediates epithelial defenses against enteric bacterial pathogens.
Leigh A. Knodler,Leigh A. Knodler,Shauna M. Crowley,Ho Pan Sham,Hyungjun Yang,Marie Wrande,Caixia Ma,Robert K. Ernst,Olivia Steele-Mortimer,Jean Celli,Jean Celli,Bruce A. Vallance +11 more
TL;DR: An epithelial cell-intrinsic noncanonical inflammasome plays a critical role in antimicrobial defense at the intestinal mucosal surface in caspase-11-deficient mice.
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The Toll–Interleukin-1 Receptor Member SIGIRR Regulates Colonic Epithelial Homeostasis, Inflammation, and Tumorigenesis
Hui Xiao,Muhammet F. Gulen,Muhammet F. Gulen,Jinzhong Qin,Jinzhong Qin,Jianhong Yao,Katarzyna Bulek,Danielle D. Kish,Cengiz Z. Altuntas,David N Wald,Caixia Ma,Hang Zhou,Vincent K. Tuohy,Robert L. Fairchild,Carol A. de la Motte,Daniel J. Cua,Bruce A. Vallance,Xiaoxia Li +17 more
TL;DR: Gut epithelium-derived SIGIRR is critical in controlling the homeostasis and innate immune responses of the colon to enteric microflora and reduced AOM+DSS-induced tumorigenesis.
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MyD88 signalling plays a critical role in host defence by controlling pathogen burden and promoting epithelial cell homeostasis during Citrobacter rodentium-induced colitis.
TL;DR: Investigating the role of MyD88 following infection by the murine bacterial pathogen Citrobacter rodentium found it to play a critical role in mediating host defence against an entericacterial pathogen, by controlling bacterial numbers and promoting intestinal epithelial homeostasis.
Journal ArticleDOI
Toll-like receptor 2 plays a critical role in maintaining mucosal integrity during Citrobacter rodentium-induced colitis.
Deanna L. Gibson,Caixia Ma,Carrie M. Rosenberger,Kirk Bergstrom,Yanet Valdez,Jingtian T. Huang,Mohammed A. Khan,Bruce A. Vallance +7 more
TL;DR: It is reported for the first time that TLR2 plays a critical role in maintaining intestinal mucosal integrity during infection by a bacterial pathogen.