Elizabeth M. Perez

TL;DR: In this paper, the effects of degrading cohesin were explored, showing that loop domains can be eliminated and re-formed in under an hour, consistent with a model where loop extrusion is rapid.

TL;DR: It is found that malignant cells in glioblastoma exist in four main cellular states that recapitulate distinct neural cell types, are influenced by the tumor microenvironment, and exhibit plasticity.

TL;DR: Cross-talk among neighbouring genes is a prevalent phenomenon that can involve multiple mechanisms and cis-regulatory signals, including a role for RNA splice sites, and mechanisms may explain the function and evolution of some genomic loci that produce lncRNAs and broadly contribute to the regulation of both coding and non-coding genes.

TL;DR: A simple activity-by-contact model substantially outperformed previous methods at predicting the complex connections in the CRISPR dataset and allows systematic mapping of enhancer–gene connections in a given cell type, on the basis of chromatin-state measurements.

TL;DR: A high-throughput approach that uses clustered regularly interspaced short palindromic repeats (CRISPRi) interference to discover regulatory elements and identify their target genes and can be applied to dissect transcriptional networks and interpret the contributions of noncoding genetic variation to human disease.