K
Kamil Slowikowski
Researcher at Broad Institute
Publications - 52
Citations - 8461
Kamil Slowikowski is an academic researcher from Broad Institute. The author has contributed to research in topics: Population & Expression quantitative trait loci. The author has an hindex of 25, co-authored 52 publications receiving 4846 citations. Previous affiliations of Kamil Slowikowski include Massachusetts Institute of Technology & Brigham and Women's Hospital.
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Journal ArticleDOI
Fast, sensitive and accurate integration of single-cell data with Harmony.
Ilya Korsunsky,Nghia Millard,Jean Fan,Kamil Slowikowski,Fan Zhang,Kevin Wei,Yuriy Baglaenko,Michael B. Brenner,Po-Ru Loh,Po-Ru Loh,Po-Ru Loh,Soumya Raychaudhuri +11 more
TL;DR: Harmony, for the integration of single-cell transcriptomic data, identifies broad and fine-grained populations, scales to large datasets, and can integrate sequencing- and imaging-based data.
Journal ArticleDOI
Heritability enrichment of specifically expressed genes identifies disease-relevant tissues and cell types.
Hilary K. Finucane,Hilary K. Finucane,Hilary K. Finucane,Yakir A. Reshef,Verneri Anttila,Verneri Anttila,Kamil Slowikowski,Kamil Slowikowski,Kamil Slowikowski,Alexander Gusev,Andrea Byrnes,Andrea Byrnes,Steven Gazal,Po-Ru Loh,Caleb A. Lareau,Caleb A. Lareau,Noam Shoresh,Giulio Genovese,Arpiar Saunders,Evan Z. Macosko,Samuela Pollack,John R. B. Perry,Jason D. Buenrostro,Jason D. Buenrostro,Bradley E. Bernstein,Bradley E. Bernstein,Soumya Raychaudhuri,Steven A. McCarroll,Steven A. McCarroll,Benjamin M. Neale,Benjamin M. Neale,Alkes L. Price,Alkes L. Price +32 more
TL;DR: An approach to identify disease-relevant tissues and cell types by analyzing gene expression data together with genome-wide association study (GWAS) summary statistics and found significant tissue-specific enrichments for 34 traits.
Journal ArticleDOI
Pathologically expanded peripheral T helper cell subset drives B cells in rheumatoid arthritis
Deepak A. Rao,Michael F. Gurish,Jennifer L. Marshall,Kamil Slowikowski,Chamith Y. Fonseka,Yanyan Liu,Laura T. Donlin,Lauren A. Henderson,Kevin Wei,Fumitaka Mizoguchi,Nikola Teslovich,Nikola Teslovich,Michael E. Weinblatt,Elena Massarotti,Jonathan S. Coblyn,Simon M. Helfgott,Yvonne C. Lee,Derrick J. Todd,Vivian P. Bykerk,Susan M. Goodman,Susan M. Goodman,Alessandra B. Pernis,Lionel B. Ivashkiv,Elizabeth W. Karlson,Peter A. Nigrovic,Peter A. Nigrovic,Andrew Filer,Christopher D. Buckley,James A. Lederer,Soumya Raychaudhuri,Michael B. Brenner +30 more
TL;DR: Using multidimensional cytometry, transcriptomics, and functional assays, a population of PD-1hiCXCR5− ‘peripheral helper’ T (TPH) cells that express factors enabling B-cell help, including IL-21, CXCL13, ICOS, and MAF are defined.
Journal ArticleDOI
Defining inflammatory cell states in rheumatoid arthritis joint synovial tissues by integrating single-cell transcriptomics and mass cytometry.
Fan Zhang,Kevin Wei,Kamil Slowikowski,Chamith Y. Fonseka,Deepak A. Rao,Stephen Kelly,Susan M. Goodman,Susan M. Goodman,Darren Tabechian,Laura B. Hughes,Karen Salomon-Escoto,Gerald F. Watts,A. Helena Jonsson,Javier Rangel-Moreno,Nida Meednu,Cristina Rozo,William Apruzzese,Thomas Eisenhaure,David J. Lieb,David L. Boyle,Arthur M. Mandelin,Brendan F. Boyce,Edward F. DiCarlo,Ellen M. Gravallese,Peter K. Gregersen,Larry W. Moreland,Gary S. Firestein,Nir Hacohen,Chad Nusbaum,James A. Lederer,Harris Perlman,Costantino Pitzalis,Andrew Filer,V. Michael Holers,Vivian P. Bykerk,Vivian P. Bykerk,Laura T. Donlin,Laura T. Donlin,Jennifer H. Anolik,Michael B. Brenner,Soumya Raychaudhuri +40 more
TL;DR: Several single-cell -omics approaches are used to define the cellular processes and pathways in the human RA joint and attributed IL6 expression to THY1+HLA-DRAhi fibroblasts and IL1B production to pro-inflammatory monocytes, potentially key mediators of RA pathogenesis.
Journal ArticleDOI
The immune cell landscape in kidneys of patients with lupus nephritis
Arnon Arazi,Deepak A. Rao,Celine C. Berthier,Anne Davidson,Yanyan Liu,Paul Hoover,Adam Chicoine,Thomas Eisenhaure,A. Helena Jonsson,Shuqiang Li,David J. Lieb,Fan Zhang,Kamil Slowikowski,Edward P. Browne,Akiko Noma,Danielle Sutherby,Scott Steelman,Dawn E. Smilek,Patti Tosta,William Apruzzese,Elena Massarotti,Maria Dall'Era,Meyeon Park,Diane L. Kamen,Richard A. Furie,Fernanda Payan-Schober,William F. Pendergraft,Elizabeth A. McInnis,Jill P. Buyon,Michelle Petri,Chaim Putterman,Kenneth C. Kalunian,E. Steve Woodle,James A. Lederer,David A. Hildeman,David A. Hildeman,Chad Nusbaum,Soumya Raychaudhuri,Matthias Kretzler,Jennifer H. Anolik,Michael B. Brenner,David Wofsy,Nir Hacohen,Betty Diamond +43 more
TL;DR: Analysis of kidney samples from patients with lupus nephritis and healthy control subjects revealed 21 subsets of leukocytes active in disease, including multiple populations of myeloid cells, T cells, natural killer cells and B cells that demonstrated both pro-inflammatory responses and inflammation-resolving responses.