Camilla Basso

TL;DR: Elevating L-arginine levels induced global metabolic changes including a shift from glycolysis to oxidative phosphorylation in activated T cells and promoted the generation of central memory-like cells endowed with higher survival capacity and, in a mouse model, anti-tumor activity.

TL;DR: How pathogenic T cells can enter into intact or inflamed central nervous system to cause experimental autoimmune encephalomyelitis or multiple sclerosis is described and the role of CCR6/CCL20 axis in migration through the choroid plexus is elaborate.

TL;DR: An engineered probiotic Escherichia coli Nissle 1917 strain that colonizes tumors and continuously converts ammonia, a metabolic waste product that accumulates in tumors4, into L-arginine shows that engineered microbial therapies enable metabolic modulation of the tumor microenvironment leading to enhanced efficacy of immunotherapies.

TL;DR: Light is shed on the enigmatic function of PTX in EAE induction and inflammatory monocytes and microbial infection can influence differentiation of pathogenic Th1/Th17 cells in autoimmune diseases through production of IL-1β.

TL;DR: It is shown that miR-181a is selectively induced in both human and mouse naive T cells differentiating into the TH17, but not TH1 or TH2 subset, thus influencing memory responses.