Carl Shanholtz

TL;DR: The reduced tidal volume strategy used in this study was safe and effective and failure to observe beneficial effects of small tidal volume ventilation treatment in important clinical outcome variables may have occurred because a) the sample size was too small to discern small treatment effects; b) the differences in tidal volumes and plateau pressures were modest; or c) reduced tidalVolume ventilation is not beneficial.

TL;DR: Muscle weakness is common after acute lung injury, usually recovering within 12 months, and this weakness is associated with substantial impairments in physical function and health-related quality of life that continue beyond 24 months.

TL;DR: Rosuvastatin therapy did not improve clinical outcomes in patients with sepsis-associated ARDS and may have contributed to hepatic and renal organ dysfunction, and was not associated with an increased incidence of serum creatine kinase levels that were more than 10 times the upper limit of the normal range.

TL;DR: Lung protective mechanical ventilation was associated with a substantial long term survival benefit for patients with acute lung injury and greater use of lung protective ventilation in routine clinical practice could reduce long term mortality in patients with chronic lung injury.

TL;DR: Hypermorphic genetic variation in TLR1 is associated with increased susceptibility to organ dysfunction, death, and gram-positive infection in sepsis.