C
Carla Andrea Klattenhoff
Researcher at University of Massachusetts Medical School
Publications - 11
Citations - 3251
Carla Andrea Klattenhoff is an academic researcher from University of Massachusetts Medical School. The author has contributed to research in topics: RasiRNA & Piwi-interacting RNA. The author has an hindex of 9, co-authored 10 publications receiving 2984 citations. Previous affiliations of Carla Andrea Klattenhoff include Massachusetts Institute of Technology.
Papers
More filters
Journal ArticleDOI
Braveheart, a Long Noncoding RNA Required for Cardiovascular Lineage Commitment
Carla Andrea Klattenhoff,Johanna C. Scheuermann,Lauren E. Surface,Robert K. Bradley,Paul A. Fields,Matthew L. Steinhauser,Huiming Ding,Vincent L. Butty,Lillian Torrey,Simon Haas,Ryan Abo,Mohammadsharif Tabebordbar,Mohammadsharif Tabebordbar,Richard T. Lee,Richard T. Lee,Christopher B. Burge,Laurie A. Boyer +16 more
TL;DR: Braveheart (Bvht), a heart-associated lncRNA in mouse is identified and it is found that Bvht is necessary for activation of a core cardiovascular gene network and functions upstream of mesoderm posterior 1 (MesP1), a master regulator of a common multipotent cardiovascular progenitor.
Journal ArticleDOI
Normal microRNA Maturation and Germ-Line Stem Cell Maintenance Requires Loquacious, a Double-Stranded RNA-Binding Domain Protein
Klaus Förstemann,Yukihide Tomari,Tingting Du,Vasily V. Vagin,Ahmet M. Denli,Diana P. Bratu,Carla Andrea Klattenhoff,William E. Theurkauf,Phillip D. Zamore +8 more
TL;DR: It is shown that normal processing of Drosophila pre-miRNAs by Dicer-1 requires the double-stranded RNA-binding domain (dsRBD) protein Loquacious (Loqs), a homolog of human TRBP, a protein first identified as binding the HIV trans-activator RNA (TAR).
Journal ArticleDOI
Collapse of Germline piRNAs in the Absence of Argonaute3 Reveals Somatic piRNAs in Flies
Chengjian Li,Vasily V. Vagin,Soohyun Lee,Soohyun Lee,Jia Xu,Jia Xu,Shengmei Ma,Hualin Xi,Hualin Xi,Hervé Seitz,Michael D. Horwich,Monika Syrzycka,Barry M. Honda,Ellen L. W. Kittler,Maria L. Zapp,Carla Andrea Klattenhoff,Nadine Schulz,William E. Theurkauf,Zhiping Weng,Phillip D. Zamore +19 more
TL;DR: Strong loss-of-function mutations in ago3 are described and it is found that Ago3 acts to amplify piRNA pools and to enforce on them an antisense bias, increasing the number of piRNAs that can act to silence transposons.
Journal ArticleDOI
Biogenesis and germline functions of piRNAs.
TL;DR: Whether piRNAs primarily control chromatin organization, gene transcription, RNA stability or RNA translation is not well understood, neither is piRNA biogenesis, and unanswered questions are discussed.
Journal ArticleDOI
The Drosophila HP1 Homolog Rhino Is Required for Transposon Silencing and piRNA Production by Dual-Strand Clusters
Carla Andrea Klattenhoff,Hualin Xi,Hualin Xi,Hualin Xi,Chengjian Li,Soohyun Lee,Soohyun Lee,Jia Xu,Jia Xu,Jaspreet S. Khurana,Fan Zhang,Nadine Schultz,Birgit S. Koppetsch,Anetta Nowosielska,Hervé Seitz,Hervé Seitz,Hervé Seitz,Phillip D. Zamore,Zhiping Weng,William E. Theurkauf +19 more
TL;DR: It is shown that the HP1 homolog Rhino is required for nuage organization, transposon silencing, and ping-pong amplification of piRNAs, and appears to promote transcription of dual-strand clusters, leading to production ofPiRNAs that drive the ping- pong amplification cycle.