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Carla Oseroff
Researcher at La Jolla Institute for Allergy and Immunology
Publications - 64
Citations - 7346
Carla Oseroff is an academic researcher from La Jolla Institute for Allergy and Immunology. The author has contributed to research in topics: Epitope & T cell. The author has an hindex of 40, co-authored 64 publications receiving 6825 citations. Previous affiliations of Carla Oseroff include Johns Hopkins University.
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Journal Article
The relationship between class I binding affinity and immunogenicity of potential cytotoxic T cell epitopes.
Alessandro Sette,A Vitiello,B. Reherman,P Fowler,R. Nayersina,Wybe Martin Kast,Cornelis J. M. Melief,Carla Oseroff,L Yuan,Jörg Ruppert,J Sidney,M F del Guercio,Scott Southwood,Ralph T. Kubo,R W Chesnut,Howard M. Grey,Francis V. Chisari +16 more
TL;DR: The data suggest that holes in the functional T cell repertoire, if they exist, may be relatively rare and correlate well with class I binding affinity measurements of either naturally processed peptides or previously described T cell epitopes.
Journal ArticleDOI
Development of high potency universal DR-restricted helper epitopes by modification of high affinity DR-blocking peptides
Jeff Alexander,John Sidney,Scott Southwood,Jörg Ruppert,Carla Oseroff,Ajesh Maewal,Ken Snoke,Horacio Serra,Ralph T. Kubo,Alessandro Sette,Howard M. Grey +10 more
TL;DR: Pan DR-binding peptides engineered by introducing anchor residues for different DR motifs within a polyalanine backbone bound 10 of 10 DR molecules tested, with affinities, in most cases, in the nanomolar range.
Journal ArticleDOI
T cells from patients with Parkinson’s disease recognize α-synuclein peptides
David Sulzer,Roy N. Alcalay,Francesca Garretti,Lucien J. Cote,Ellen Kanter,Julian Agin-Liebes,Christopher Liong,Curtis McMurtrey,William H. Hildebrand,Xiaobo Mao,Valina L. Dawson,Ted M. Dawson,Carla Oseroff,John Pham,John Sidney,Myles B.C. Dillon,Chelsea Carpenter,Daniela Weiskopf,Elizabeth J. Phillips,Elizabeth J. Phillips,Simon Mallal,Simon Mallal,Bjoern Peters,April Frazier,Cecilia S. Lindestam Arlehamn,Alessandro Sette +25 more
TL;DR: It is shown that a defined set of peptides that are derived from α-synuclein, a protein aggregated in Parkinson’s disease, act as antigenic epitopes displayed by these alleles and drive helper and cytotoxic T cell responses in patients with Parkinson's disease.
Journal Article
Human CTL epitopes encoded by human papillomavirus type 16 E6 and E7 identified through in vivo and in vitro immunogenicity studies of HLA-A*0201-binding peptides.
Maaike E. Ressing,A Sette,R.M.P. Brandt,Jörg Ruppert,P A Wentworth,M. Hartman,Carla Oseroff,Howard M. Grey,Cornelis J. M. Melief,Wybe Martin Kast +9 more
TL;DR: In mice, the outgrowth of a lethal dose of HPV16-induced tumor cells has been prevented by vaccination with a CTL epitope encoded by HPV16 E7, indicating the feasibility of peptide immunization to obtain antitumor CTL responses.
Journal ArticleDOI
Drug hypersensitivity caused by alteration of the MHC-presented self-peptide repertoire
David A. Ostrov,Barry J. Grant,Yuri A. Pompeu,John Sidney,Mikkel Harndahl,Scott Southwood,Carla Oseroff,Shun Lu,Jean Jakoncic,César Augusto F. de Oliveira,Lun Yang,Hu Mei,Leming Shi,Jeffrey Shabanowitz,A. Michelle English,Amanda Wriston,Andrew Lucas,Elizabeth J. Phillips,Simon Mallal,Howard M. Grey,Alessandro Sette,Donald F. Hunt,Søren Buus,Bjoern Peters +23 more
TL;DR: It is shown that abacavir can bind within the F pocket of the peptide-binding groove of HLA-B*57:01, thereby altering its specificity, namely that drugs can alter the repertoire of self-peptides presented to T cells, thus causing the equivalent of an alloreactive T-cell response.