C
Carles Cantó
Researcher at Nestlé
Publications - 88
Citations - 16810
Carles Cantó is an academic researcher from Nestlé. The author has contributed to research in topics: NAD+ kinase & Skeletal muscle. The author has an hindex of 46, co-authored 79 publications receiving 14037 citations. Previous affiliations of Carles Cantó include École Polytechnique Fédérale de Lausanne & University of Barcelona.
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Journal ArticleDOI
Nicotinamide riboside kinases display redundancy in mediating nicotinamide mononucleotide and nicotinamide riboside metabolism in skeletal muscle cells
Rachel Fletcher,Rachel Fletcher,Joanna Ratajczak,Joanna Ratajczak,Craig L. Doig,Craig L. Doig,Lucy Oakey,Rebecca Callingham,Gabriela da Silva Xavier,Antje Garten,Antje Garten,Yasir S Elhassan,Yasir S Elhassan,Philip Redpath,Marie E. Migaud,Andrew Philp,Charles Brenner,Carles Cantó,Carles Cantó,Gareth G. Lavery,Gareth G. Lavery +20 more
TL;DR: These results identify skeletal muscle cells as requiring NAMPT to maintain NAD+ availability and reveal that NRK1 and 2 display overlapping function in salvage of exogenous NR and NMN to augment intracellular NAD+availability.
Journal ArticleDOI
A reduced form of nicotinamide riboside defines a new path for NAD+ biosynthesis and acts as an orally bioavailable NAD+ precursor
Judith Giroud-Gerbetant,Magali Joffraud,Maria Pilar Giner,Angelique Cercillieux,Simona Bartova,Mikhail V. Makarov,Rubén Zapata-Pérez,Jose L. Sanchez-Garcia,Riekelt H. Houtkooper,Marie E. Migaud,Sofia Moco,Carles Cantó,Carles Cantó +12 more
TL;DR: It is found that NRH uses different steps and enzymes to synthesize NAD+, thus revealing a new NRK1-independent pathway for NAD+ synthesis, and is classified as a promising new therapeutic strategy to enhance NAD+ levels.
Journal ArticleDOI
SIRT1 enhances glucose tolerance by potentiating brown adipose tissue function
Marie Boutant,Magali Joffraud,Sameer S. Kulkarni,Ester García-Casarrubios,Pablo M. Garcia-Roves,Joanna Ratajczak,Joanna Ratajczak,Pablo J. Fernandez-Marcos,Ángela M. Valverde,Manuel Serrano,Carles Cantó +10 more
TL;DR: This work demonstrates that SIRT1 improves glucose homeostasis by enhancing BAT function as a result of potentiating the response to β3-adrenergic stimuli.
Journal ArticleDOI
Circadian and Feeding Rhythms Orchestrate the Diurnal Liver Acetylome.
Daniel Mauvoisin,Daniel Mauvoisin,Florian Atger,Florian Atger,Loïc Dayon,Antonio Núñez Galindo,Jingkui Wang,Eva Martin,Laetitia Da Silva,Ivan Montoliu,Sebastiano Collino,François-Pierre Martin,Joanna Ratajczak,Joanna Ratajczak,Carles Cantó,Carles Cantó,Martin Kussmann,Felix Naef,Frédéric Gachon,Frédéric Gachon +19 more
TL;DR: The diurnal acetylome relies on a functional circadian clock and affects important diurnal metabolic pathways in the mouse liver and it is shown that NAD+ is orchestrated by both feeding rhythms and the circadian clock through the NAD+ salvage pathway but also via the nicotinamide riboside pathway.
Journal ArticleDOI
Distinct patterns of skeletal muscle mitochondria fusion, fission and mitophagy upon duration of exercise training.
Yoan Arribat,Nicholas T. Broskey,Chiara Greggio,Marie Boutant,Sonia Conde Alonso,Sameer S. Kulkarni,Sylviane Lagarrigue,Elvis A. Carnero,Cyril Besson,Carles Cantó,Francesca Amati +10 more
TL;DR: Fusion, fission and mitophagy are investigated before and after an exercise intervention in older adults to investigate mitochondrial remodelling in response to exercise training.