C
Carlo Presutti
Researcher at Sapienza University of Rome
Publications - 41
Citations - 2019
Carlo Presutti is an academic researcher from Sapienza University of Rome. The author has contributed to research in topics: Regulation of gene expression & microRNA. The author has an hindex of 23, co-authored 40 publications receiving 1837 citations. Previous affiliations of Carlo Presutti include National Research Council & University of Edinburgh.
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Journal ArticleDOI
Identification of a Regulated Pathway for Nuclear Pre-mRNA Turnover
TL;DR: It is proposed that nuclear pre-mRNA turnover represents a novel step in the regulation of gene expression and is regulated in response to carbon source.
Journal ArticleDOI
Stress induces region specific alterations in microRNAs expression in mice.
Arianna Rinaldi,Sara Vincenti,Francesca De Vito,Irene Bozzoni,Alberto Oliverio,Carlo Presutti,Paola Fragapane,Andrea Mele +7 more
TL;DR: The data suggest that control of mRNA translation through miRs is an additional mechanism by which stressful events regulates protein expression in the frontal cortex.
Journal ArticleDOI
Modulation of microRNA editing, expression and processing by ADAR2 deaminase in glioblastoma
Sara Tomaselli,Federica Galeano,Shahar Alon,Susanna Raho,Silvia Galardi,Vinicia Assunta Polito,Carlo Presutti,Sara Vincenti,Eli Eisenberg,Franco Locatelli,Franco Locatelli,Angela Gallo +11 more
TL;DR: The rescue of ADAR2 activity in cancer cells recovers the edited miRNA population lost in glioblastoma cell lines and tissues, and rebalances expression of onco-miRNAs and tumor suppressor miRNAs to the levels observed in normal human brain.
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Purified box C/D snoRNPs are able to reproduce site-specific 2'-O-methylation of target RNA in vitro
TL;DR: It is shown that purified snoRNPs are able to reproduce the site-specific methylation pattern on target RNA and that the predicted S-adenosyl-l-methionine-binding region of Nop1p is responsible for the catalytic activity.
Journal ArticleDOI
The ABF1 factor is the transcriptional activator of the L2 ribosomal protein genes in Saccharomyces cerevisiae.
F Della Seta,Silvia Anna Ciafrè,C Marck,Bina Santoro,Carlo Presutti,A Sentenac,Irene Bozzoni +6 more
TL;DR: In vitro binding experiments and in vivo functional analysis showed that the different affinities of the L2A and L2B promoters for the ABF1 factor are responsible for the differential transcriptional activities of the two gene copies.