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Carlos E. Girod
Researcher at University of Texas Southwestern Medical Center
Publications - 22
Citations - 1237
Carlos E. Girod is an academic researcher from University of Texas Southwestern Medical Center. The author has contributed to research in topics: Idiopathic pulmonary fibrosis & Lung. The author has an hindex of 10, co-authored 22 publications receiving 1013 citations. Previous affiliations of Carlos E. Girod include Anschutz Medical Campus & University of Colorado Denver.
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Journal ArticleDOI
Exome sequencing links mutations in PARN and RTEL1 with familial pulmonary fibrosis and telomere shortening
Bridget D. Stuart,Jungmin Choi,Samir Zaidi,Samir Zaidi,Chao Xing,Brody Holohan,Rui Chen,Mihwa Choi,Pooja Dharwadkar,Fernando Torres,Carlos E. Girod,Jonathan C. Weissler,John E. Fitzgerald,Corey D. Kershaw,Julia Klesney-Tait,Yolanda Mageto,Jerry W. Shay,Weizhen Ji,Weizhen Ji,Kaya Bilguvar,Shrikant Mane,Richard P. Lifton,Christine Kim Garcia +22 more
TL;DR: PARN and RTEL1 genes explain ∼7% of familial pulmonary fibrosis and strengthen the link between lung Fibrosis and telomere dysfunction.
Journal ArticleDOI
Telomere Lengths, Pulmonary Fibrosis and Telomerase (TERT) Mutations
Alberto Diaz de Leon,Jennifer T. Cronkhite,Anna Luise A Katzenstein,J. David Godwin,Ganesh Raghu,Craig S. Glazer,Randall L. Rosenblatt,Carlos E. Girod,Edward R. Garrity,Chao Xing,Christine Kim Garcia +10 more
TL;DR: A subset of pulmonary fibrosis, like dyskeratosis congenita, bone marrow failure, and liver disease, represents a “telomeropathy” caused by germline mutations in telomerase and characterized by short telomere lengths, demonstrating epigenetic inheritance of a shortened parental telomeres length set-point.
Journal ArticleDOI
Effect of telomere length on survival in patients with idiopathic pulmonary fibrosis: An observational cohort study with independent validation
Bridget D. Stuart,Joyce S. Lee,Julia Kozlitina,Imre Noth,Megan S. Devine,Craig S. Glazer,Fernando Torres,Vaidehi Kaza,Carlos E. Girod,Kirk D. Jones,Brett M. Elicker,Shwu Fan Ma,Rekha Vij,Harold R. Collard,Paul J. Wolters,Christine Kim Garcia +15 more
TL;DR: The association between telomere length and survival in patients with idiopathic pulmonary fibrosis was independent of age, sex, forced vital capacity, or diffusing capacity of carbon monoxide, and was replicated in the two independent idiopATHic pulmonary Fibrosis replication cohorts.
Journal ArticleDOI
Pulmonary prostacyclin synthase overexpression chemoprevents tobacco smoke lung carcinogenesis in mice
Robert L. Keith,Robert L. Keith,York E. Miller,York E. Miller,Tyler M. Hudish,Carlos E. Girod,Sylk Sotto-Santiago,Wilbur A. Franklin,Raphael A. Nemenoff,Thomas H. March,S. Patrick Nana-Sinkam,Mark W. Geraci +11 more
TL;DR: It is demonstrated that manipulation of prostaglandin production distal to cyclooxygenase significantly reduces lung carcinogenesis in a tobacco smoke exposure model, and gene expression studies show critical alterations in antioxidation, immune response, and cytokine pathways.
Journal ArticleDOI
Predicting out of intensive care unit cardiopulmonary arrest or death using electronic medical record data
Carlos A. Alvarez,Christopher Clark,Song Zhang,Ethan A. Halm,John J Shannon,Carlos E. Girod,Lauren Cooper,Ruben Amarasingham +7 more
TL;DR: An automated model harnessing EMR data offers great potential for identifying RED and was superior to both a prior risk model and the human judgment-driven RRT.