J
Julia Kozlitina
Researcher at University of Texas Southwestern Medical Center
Publications - 59
Citations - 7928
Julia Kozlitina is an academic researcher from University of Texas Southwestern Medical Center. The author has contributed to research in topics: Population & Nonalcoholic fatty liver disease. The author has an hindex of 18, co-authored 54 publications receiving 6201 citations. Previous affiliations of Julia Kozlitina include Southern Methodist University & Medical College of Wisconsin.
Papers
More filters
Journal ArticleDOI
Genetic variation in PNPLA3 confers susceptibility to nonalcoholic fatty liver disease
Stefano Romeo,Julia Kozlitina,Julia Kozlitina,Chao Xing,Alexander Pertsemlidis,David Cox,Len A. Pennacchio,Len A. Pennacchio,Eric Boerwinkle,Jonathan C. Cohen,Helen H. Hobbs +10 more
TL;DR: Variation in PNPLA3 contributes to ancestry-related and inter-individual differences in hepatic fat content and susceptibility to NAFLD.
Journal ArticleDOI
Exome-wide association study identifies a TM6SF2 variant that confers susceptibility to nonalcoholic fatty liver disease.
Julia Kozlitina,Eriks Smagris,Stefan Stender,Børge G. Nordestgaard,Heather Zhou,Anne Tybjærg-Hansen,Thomas F. Vogt,Helen H. Hobbs,Jonathan C. Cohen +8 more
TL;DR: Exome-wide association study of liver fat content and adeno-associated virus–mediated short hairpin RNA knockdown of Tm6sf2 in mice indicate that TM6 SF2 activity is required for normal VLDL secretion and that impaired TM6SF2 function causally contributes to NAFLD.
Journal ArticleDOI
A Protein-Truncating HSD17B13 Variant and Protection from Chronic Liver Disease
Noura S. Abul-Husn,Xiping Cheng,Alexander H. Li,Yurong Xin,Claudia Schurmann,Panayiotis Stevis,Yashu Liu,Julia Kozlitina,Stefan Stender,G. Craig Wood,Ann Stepanchick,Matthew D. Still,Shane McCarthy,Colm O'Dushlaine,Jonathan S. Packer,Suganthi Balasubramanian,Nehal Gosalia,David Esopi,Sun Y. Kim,Semanti Mukherjee,Alexander E. Lopez,Erin D. Fuller,John Penn,Xin Chu,Jonathan Z. Luo,Uyenlinh L. Mirshahi,David J. Carey,Christopher D. Still,Michael Feldman,Aeron Small,Scott M. Damrauer,Daniel J. Rader,Brian Zambrowicz,William C. Olson,Andrew J. Murphy,Ingrid B. Borecki,Alan R. Shuldiner,Jeffrey G. Reid,John D. Overton,George D. Yancopoulos,Helen H. Hobbs,Jonathan C. Cohen,Omri Gottesman,Tanya M. Teslovich,Aris Baras,Tooraj Mirshahi,Jesper Gromada,Frederick E. Dewey +47 more
TL;DR: A loss‐of‐function variant in HSD17B13 was associated with a reduced risk of chronic liver disease and of progression from steatosis to steatohepatitis.
Journal ArticleDOI
The MBOAT7-TMC4 Variant rs641738 Increases Risk of Nonalcoholic Fatty Liver Disease in Individuals of European Descent
Rosellina Margherita Mancina,Paola Dongiovanni,Salvatore Petta,Piero Pingitore,Marica Meroni,R. Rametta,Jan Borén,Tiziana Montalcini,Arturo Pujia,Olov Wiklund,Olov Wiklund,George Hindy,Rocco Spagnuolo,Benedetta Maria Motta,Rosaria Maria Pipitone,Antonio Craxì,Silvia Fargion,Valerio Nobili,Pirjo Käkelä,Vesa Kärjä,Ville Männistö,Jussi Pihlajamäki,Dermot F. Reilly,Jose Castro-Perez,Jose Castro-Perez,Julia Kozlitina,Luca Valenti,Stefano Romeo,Stefano Romeo,Stefano Romeo +29 more
TL;DR: Evidence is provided for an association between the MBOAT7 rs641738 variant and the development and severity of NAFLD in individuals of European descent that seems to be mediated by changes in the hepatic phosphatidylinositol acyl-chain remodeling.
Journal ArticleDOI
Rare loss-of-function mutations in ANGPTL family members contribute to plasma triglyceride levels in humans
Stefano Romeo,Wu Yin,Julia Kozlitina,Len A. Pennacchio,Len A. Pennacchio,Eric Boerwinkle,Helen H. Hobbs,Jonathan C. Cohen +7 more
TL;DR: ANGPTL3, Angiopoietin-like proteins, but not ANGPTL6, play nonredundant roles in TG metabolism, and multiple alleles at these loci cumulatively contribute to variability in plasma TG levels in humans.