C
Carmen Dominguez-Brauer
Researcher at University Health Network
Publications - 15
Citations - 1013
Carmen Dominguez-Brauer is an academic researcher from University Health Network. The author has contributed to research in topics: Wnt signaling pathway & T cell. The author has an hindex of 14, co-authored 15 publications receiving 819 citations. Previous affiliations of Carmen Dominguez-Brauer include Princess Margaret Cancer Centre & University of Illinois at Chicago.
Papers
More filters
Journal ArticleDOI
Targeting Mitosis in Cancer: Emerging Strategies
Carmen Dominguez-Brauer,Kelsie L. Thu,Jacqueline M. Mason,Heiko Blaser,Mark R. Bray,Tak W. Mak +5 more
TL;DR: The concept of exploiting the genomic instability of tumor cells through therapeutic inhibition of mitotic checkpoints is discussed, and it is believed this strategy has a high likelihood of success given its potential to enhance therapeutic index by targeting tumor-specific vulnerabilities.
Journal ArticleDOI
Mule/Huwe1/Arf-BP1 suppresses Ras-driven tumorigenesis by preventing c-Myc/Miz1-mediated down-regulation of p21 and p15
Satoshi Inoue,Zhenyue Hao,Andrew J. Elia,David W. Cescon,Lily Zhou,Jennifer Silvester,Bryan E. Snow,Isaac S. Harris,Masato Sasaki,Wanda Y. Li,Momoe Itsumi,Kazuo Yamamoto,Takeshi Ueda,Carmen Dominguez-Brauer,Chiara Gorrini,Iok In Christine Chio,Jillian Haight,Annick You-Ten,Susan McCracken,Andrew Wakeham,Danny Ghazarian,Linda Z. Penn,Gerry Melino,Gerry Melino,Tak W. Mak +24 more
TL;DR: It is demonstrated in vivo that Mule suppresses Ras-mediated tumorigenesis by preventing an accumulation of c-Myc/Miz1 complexes that mediates p21 and p15 down-regulation.
Journal ArticleDOI
A conserved phosphorylation site within the forkhead domain of FoxM1b is required for its activation by cyclin-Cdk1
Yi Ju Chen,Carmen Dominguez-Brauer,Zebin Wang,John M. Asara,John M. Asara,Robert H. Costa,Angela L. Tyner,Lester F. Lau,Pradip Raychaudhuri +8 more
TL;DR: The results demonstrate that the transcriptional activity of FoxM1 is controlled in a cell cycle-dependent fashion by temporally regulated phosphorylated and dephosphorylation events, and that the phosphorylation at Ser-251 is critical for the activation of Foxm1.
Journal ArticleDOI
Choline acetyltransferase-expressing T cells are required to control chronic viral infection.
Maureen A. Cox,Gordon Duncan,Gloria H. Y. Lin,Benjamin E. Steinberg,Benjamin E. Steinberg,Lisa X. Yu,Dirk Brenner,Dirk Brenner,Luke N. Buckler,Andrew J. Elia,Andrew Wakeham,Brian J. Nieman,Carmen Dominguez-Brauer,Alisha R. Elford,Kyle T. Gill,Shawn P. Kubli,Jillian Haight,Thorsten Berger,Pamela S. Ohashi,Pamela S. Ohashi,Kevin J. Tracey,Peder S. Olofsson,Peder S. Olofsson,Tak W. Mak +23 more
TL;DR: The results reveal a genetic proof of function for ChAT in T cells during viral infection and identify a pathway of T cell migration that sustains antiviral immunity.
Journal ArticleDOI
Ablating the aryl hydrocarbon receptor (AhR) in CD11c+ cells perturbs intestinal epithelium development and intestinal immunity.
Song Hui Chng,Parag Kundu,Carmen Dominguez-Brauer,Wei Ling Teo,Kaname Kawajiri,Yoshiaki Fujii-Kuriyama,Tak W. Mak,Sven Pettersson,Sven Pettersson +8 more
TL;DR: It is reported that Cre-mediated deletion of AhR in CD11c-expressing cells in C57/BL6 mice is associated with altered intestinal epithelial morphogenesis in vivo, and this results are consistent with a model whereby the AhR signalling pathway may participate in the regulation of innate immunity through intestinal epithelium development and mucosal immunity.