C
Carmen M. Collazo
Researcher at National Institutes of Health
Publications - 8
Citations - 1661
Carmen M. Collazo is an academic researcher from National Institutes of Health. The author has contributed to research in topics: Intracellular parasite & Interferon gamma. The author has an hindex of 8, co-authored 8 publications receiving 1580 citations.
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Journal ArticleDOI
Conventional T-bet(+)Foxp3(-) Th1 cells are the major source of host-protective regulatory IL-10 during intracellular protozoan infection.
Dragana Jankovic,Marika C. Kullberg,Carl G. Feng,Romina S. Goldszmid,Carmen M. Collazo,Mark D. Wilson,Thomas A. Wynn,Masahito Kamanaka,Richard A. Flavell,Alan Sher +9 more
TL;DR: In this article, the source of regulatory IL-10 in mice infected with the protozoan parasite Toxoplasma gondii was analyzed and it was found that the same IFN-10(+)IFN-gamma(gamma) population displayed potent effector function against the parasite while, paradoxically, also inducing profound suppression of IL-12 production by antigen-presenting cells.
Journal ArticleDOI
Inactivation of Lrg-47 and Irg-47 Reveals a Family of Interferon γ–Inducible Genes with Essential, Pathogen-Specific Roles in Resistance to Infection
Carmen M. Collazo,George S. Yap,Gregory D. Sempowski,Kimberly C. Lusby,Kimberly C. Lusby,Lino Tessarollo,George F. Vande Woude,Alan Sher,Gregory A. Taylor,Gregory A. Taylor +9 more
TL;DR: LRG- 47 and IRG-47 have vital, but distinct roles in immune defense against protozoan and bacterial infections.
Journal ArticleDOI
In the absence of IL-12, CD4(+) T cell responses to intracellular pathogens fail to default to a Th2 pattern and are host protective in an IL-10(-/-) setting.
TL;DR: MyD88-deficient animals exposed to a Th1 microbial stimulus developed a pure Th2 response, arguing that this signaling element plays a more critical function than IL-12 in determining pathogen-induced CD4 polarization.
Journal ArticleDOI
Pathogen-specific loss of host resistance in mice lacking the IFN-γ-inducible gene IGTP
Gregory A. Taylor,Carmen M. Collazo,George S. Yap,Khuong B. Nguyen,Theresa A. Gregorio,Lynn S. Taylor,Bryn Eagleson,Lisa Secrest,Eileen Southon,Susan W. Reid,Lino Tessarollo,Mike Bray,Dan W. McVicar,Kristin L. Komschlies,Howard A. Young,Christine A. Biron,Alan Sher,George F. Vande Woude +17 more
TL;DR: IGTP defines an IFN-γ-regulated pathway with a specialized role in antimicrobial resistance and generates IGTP-deficient mice, which display a profound loss of host resistance to acute infections of the protozoan parasite Toxoplasma gondii.
Journal ArticleDOI
The function of gamma interferon-inducible GTP-binding protein IGTP in host resistance to Toxoplasma gondii is Stat1 dependent and requires expression in both hematopoietic and nonhematopoietic cellular compartments.
Carmen M. Collazo,George S. Yap,Sara Hieny,Patricia Caspar,Carl G. Feng,Gregory A. Taylor,Alan Sher +6 more
TL;DR: It is demonstrated that host resistance mediated by IGTP is a Stat1-induced function which in the case of T. gondii acts predominantly to restrict acute as opposed to chronic infection.