C
Carol Sheppard
Researcher at Imperial College London
Publications - 25
Citations - 536
Carol Sheppard is an academic researcher from Imperial College London. The author has contributed to research in topics: RNA polymerase & Transcription (biology). The author has an hindex of 13, co-authored 22 publications receiving 407 citations. Previous affiliations of Carol Sheppard include University College London & Saint Petersburg State Polytechnic University.
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The SARS-CoV-2 variants associated with infections in India, B.1.617, show enhanced spike cleavage by furin
Thomas P. Peacock,Carol Sheppard,Jonathan Brown,Niluka Goonawardane,Jie Zhou,Max Whiteley,Thushan I de Silva,Wendy S. Barclay +7 more
TL;DR: The spike glycoprotein of the SARS-CoV-2 virus that emerged in 2019 contained a suboptimal furin cleavage site at the S1/S2 junction with the sequence 681PRRAR/S686.1.2 as discussed by the authors.
Journal ArticleDOI
RASSF7 Is a Member of a New Family of RAS Association Domain–containing Proteins and Is Required for Completing Mitosis
TL;DR: RASSF7, the first member of the N-terminal RASSF family to be functionally analyzed, is a centrosome-associated protein required to form a spindle and complete mitosis in the neural tube.
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ANP32 Proteins Are Essential for Influenza Virus Replication in Human Cells.
Ecco Staller,Carol Sheppard,Peter J. Neasham,Bhakti Mistry,Thomas P. Peacock,Daniel H. Goldhill,Jason S. Long,Wendy S. Barclay +7 more
TL;DR: The approach has identified a pair of essential host factors for influenza virus replication and can be harnessed to inform future interventions.
Journal ArticleDOI
Archaeal TFEα/β is a hybrid of TFIIE and the RNA polymerase III subcomplex hRPC62/39.
Fabian Blombach,Enrico Salvadori,Thomas Fouqueau,Jun Yan,Julia Reimann,Carol Sheppard,Katherine Smollett,Sonja-Verena Albers,Christopher W. M. Kay,Konstantinos Thalassinos,Finn Werner +10 more
TL;DR: The results suggest that archaeal TFEα/β is likely to represent the evolutionary ancestor of TFIIE-like factors in extant eukaryotes and to be related to the RNAPIII subunit hRPC39.
Journal ArticleDOI
Structural and mechanistic basis for the inhibition of Escherichia coli RNA polymerase by T7 Gp2.
Ellen H. James,Minhao Liu,Carol Sheppard,Vladimir Mekler,Beatriz Cámara,Bing Liu,Peter Simpson,Ernesto Cota,Konstantin Severinov,Konstantin Severinov,Steve Matthews,Sivaramesh Wigneshweraraj +11 more
TL;DR: The inhibition of Ec RNAp by Gp2 thus defines a previously uncharacterized mechanism by which bacterial transcription is regulated by a viral factor.