C
Caroline Duval
Researcher at Wageningen University and Research Centre
Publications - 9
Citations - 1522
Caroline Duval is an academic researcher from Wageningen University and Research Centre. The author has contributed to research in topics: Adipose tissue & Peroxisome proliferator-activated receptor. The author has an hindex of 6, co-authored 8 publications receiving 1339 citations.
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Journal ArticleDOI
Kupffer cells promote hepatic steatosis via interleukin-1β–dependent suppression of peroxisome proliferator-activated receptor α activity
Rinke Stienstra,Fredy Z. Saudale,Caroline Duval,Shohreh Keshtkar,Johanna E. M. Groener,Nico van Rooijen,Bart Staels,Sander Kersten,Michael Müller +8 more
TL;DR: In this article, the effect of Kupffer cells on hepatic triglyceride storage was investigated in mice rendered obese and steatotic by chronic high-fat feeding were treated for 1 week with clodronate liposomes.
Journal ArticleDOI
Saturated fat stimulates obesity and hepatic steatosis and affects gut microbiota composition by an enhanced overflow of dietary fat to the distal intestine
Nicole de Wit,Muriel Derrien,Hanneke Bosch-Vermeulen,Els Oosterink,Shohreh Keshtkar,Caroline Duval,Johan de Vogel-van den Bosch,Michiel Kleerebezem,Michael Müller,Roelof van der Meer +9 more
TL;DR: It is indicated that saturated fat (HF-PO) has a more stimulatory effect on weight gain and hepatic lipid accumulation than unsaturated fat ( HF-OO and HF-SO).
Journal ArticleDOI
PPARs, Obesity, and Inflammation.
TL;DR: The role of PPARs in obesity-induced inflammation specifically in adipose tissue, liver, and the vascular wall is addressed, with a growing recognition that obesity represents a state of chronic low-level inflammation.
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PPARalpha and dyslipidemia.
TL;DR: In this paper, a new perspective on the molecular mechanisms underlying the plasma lipoprotein modulating effect of peroxisome proliferator-activated receptor alpha (PPARalpha) is presented.
Journal ArticleDOI
Peroxisome proliferator-activated receptor gamma activation promotes infiltration of alternatively activated macrophages into adipose tissue.
Rinke Stienstra,Caroline Duval,Shohreh Keshtkar,Jeroen van der Laak,Sander Kersten,Michael Müller +5 more
TL;DR: The results suggest that short term rosiglitazone treatment increases infiltration of alternatively activated macrophages in adipose tissue, which might play a role in peroxisome proliferator-activated receptorγ-dependent expansion and remodeling of adipose tissues.