T
Torsten Witte
Researcher at Hannover Medical School
Publications - 278
Citations - 10866
Torsten Witte is an academic researcher from Hannover Medical School. The author has contributed to research in topics: Medicine & Single-nucleotide polymorphism. The author has an hindex of 49, co-authored 243 publications receiving 9239 citations. Previous affiliations of Torsten Witte include Marche Polytechnic University & Leiden University Medical Center.
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Journal ArticleDOI
The EUROclass trial: defining subgroups in common variable immunodeficiency
Claudia Wehr,Teemu Kivioja,Christian Schmitt,Berne Ferry,Torsten Witte,Efrem Eren,Marcela Vlková,M. Hernández,Drahomíra Detková,Philip R. Bos,Gonke Poerksen,Horst von Bernuth,Ulrich Baumann,Sigune Goldacker,Sylvia Gutenberger,Michael Schlesier,Florence Bergeron-van der Cruyssen,Magali Le Garff,Patrice Debré,Roland Jacobs,John R Jones,E. Bateman,Jiri Litzman,P. Martin van Hagen,Alessandro Plebani,Reinhold E. Schmidt,Vojtech Thon,Isabella Quinti,Teresa Espanol,A. David B. Webster,Helen Chapel,Mauno Vihinen,Eric Oksenhendler,Hans-Hartmut Peter,Klaus Warnatz +34 more
TL;DR: The clinical evaluation of 303 patients with the established diagnosis of CVID demonstrated a significant coincidence of granulomatous disease, autoimmune cytopenia, and splenomegaly, and an improved classification for CVID (EUROclass), separating patients with nearly absent B cells, and expansion of transitional or CD21(low) B cells.
Journal ArticleDOI
Autosomal dominant immune dysregulation syndrome in humans with CTLA4 mutations.
Desirée Schubert,Desirée Schubert,Claudia Bode,Rupert Kenefeck,Tie Zheng Hou,James B. Wing,Alan Kennedy,Alla Bulashevska,Britt-Sabina Petersen,Alejandro A. Schäffer,Björn Grüning,Susanne Unger,Natalie Frede,Ulrich Baumann,Torsten Witte,Reinhold E. Schmidt,G Dueckers,Tim Niehues,Suranjith L. Seneviratne,Maria Kanariou,Carsten Speckmann,Stephan Ehl,Anne Rensing-Ehl,Klaus Warnatz,Mirzokhid Rakhmanov,Robert Thimme,Peter Hasselblatt,Florian Emmerich,Toni Cathomen,Rolf Backofen,Paul Fisch,Maximilian Seidl,Annette M. May,Annette Schmitt-Graeff,Shinji Ikemizu,Ulrich Salzer,Andre Franke,Shimon Sakaguchi,Lucy S. K. Walker,David M. Sansom,Bodo Grimbacher +40 more
TL;DR: Taking together, mutations in CTLA4 resulting inCTLA-4 haploinsufficiency or impaired ligand binding result in disrupted T and B cell homeostasis and a complex immune dysregulation syndrome.
Journal ArticleDOI
International recommendations for the assessment of autoantibodies to cellular antigens referred to as anti-nuclear antibodies
Nancy Agmon-Levin,Nancy Agmon-Levin,Jan Damoiseaux,Cornelis Kallenberg,Ulrich Sack,Torsten Witte,Manfred Herold,Manfred Herold,Xavier Bossuyt,L. Musset,Ricard Cervera,Aresio Plaza-Lopez,Carlos Tadeu dos Santos Dias,Maria José Rego Sousa,Antonella Radice,Catharina Eriksson,Olof Hultgren,Markku Viander,Munther A. Khamashta,Stephan Regenass,Luis Eduardo Coelho Andrade,Allan Wiik,Angela Tincani,Johan Rönnelid,Daniel Bloch,Marvin J. Fritzler,Edward K. L. Chan,I. Garcia-De La Torre,Konstantin N. Konstantinov,Robert Lahita,Merlin R. Wilson,Olli Vainio,Nicole Fabien,Renato Alberto Sinico,Pier Luigi Meroni,Yehuda Shoenfeld,Yehuda Shoenfeld +36 more
TL;DR: Recommendations for the assessment and interpretation of ANA and associated antibodies were formulated and the roles of IIFA as a reference method, and the importance of defining nuclear and cytoplasmic staining were emphasised, while the need to incorporate alternative automated methods was acknowledged.
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Functional variants in the B-cell gene BANK1 are associated with systemic lupus erythematosus
Sergey V. Kozyrev,Anna Karin Abelson,Jérôme Wojcik,Ammar Zaghlool,M.V. Prasad Linga Reddy,Elena Sánchez,Iva Gunnarsson,Elisabet Svenungsson,Gunnar Sturfelt,Andreas Jönsen,Lennart Truedsson,Bernardo A. Pons-Estel,Torsten Witte,Sandra D'Alfonso,Nadia Barrizzone,Maria Giovanna Danieli,Carmen Gutiérrez,Ana Suárez,Peter Junker,Helle Laustrup,María Francisca González-Escribano,Javier Martin,Hadi Abderrahim,Marta E. Alarcón-Riquelme +23 more
TL;DR: The findings implicate BANK1 as a susceptibility gene for SLE, with variants affecting regulatory sites and key functional domains, which could contribute to sustained B cell–receptor signaling and B-cell hyperactivity characteristic of this disease.
Journal ArticleDOI
Clinical picture and treatment of 2212 patients with common variable immunodeficiency
Benjamin Gathmann,Nizar Mahlaoui,Laurence Gérard,Eric Oksenhendler,Klaus Warnatz,I. Schulze,Gerhard Kindle,Taco W. Kuijpers,Rachel T. van Beem,David Sanchez-Migallon Guzman,Sarita Workman,Pere Soler-Palacín,Javier de Gracia,Torsten Witte,Reinhold E. Schmidt,Jiri Litzman,Eva Hlaváčková,Vojtech Thon,Michael Borte,Stephan Borte,Stephan Borte,Dinakantha S. Kumararatne,Conleth Feighery,Hilary Longhurst,Matthew Helbert,Anna Szaflarska,Anna Sediva,Bernd H. Belohradsky,Alison Jones,Ulrich Baumann,Isabelle Meyts,Necil Kutukculer,Per Wågström,Nermeen Galal,Joachim Roesler,Evangelia Farmaki,Natalia Zinovieva,Peter Ciznar,Efimia Papadopoulou-Alataki,Kirsten Bienemann,Sirje Velbri,Z. Panahloo,Bodo Grimbacher,Bodo Grimbacher +43 more
TL;DR: In this article, the authors analyzed the clinical presentation, association between clinical features, and differences and effects of immunoglobulin treatment in Europe for Common Variable Immunodeficiency (CVID) patients.