C
Casper Hempel
Researcher at Technical University of Denmark
Publications - 44
Citations - 867
Casper Hempel is an academic researcher from Technical University of Denmark. The author has contributed to research in topics: Cerebral Malaria & Plasmodium berghei. The author has an hindex of 15, co-authored 39 publications receiving 740 citations. Previous affiliations of Casper Hempel include University of Sydney & University of Copenhagen.
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Journal ArticleDOI
Recombinant human erythropoietin increases survival and reduces neuronal apoptosis in a murine model of cerebral malaria.
TL;DR: Treatment with rhEpo increased survival in mice with CM in a dose- and time-dependent manner and reduced apoptotic cell death of neurons as well as the expression of pro-inflammatory cytokines in the brain.
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Formation of hydroxyl radicals contributes to the bactericidal activity of ciprofloxacin against Pseudomonas aeruginosa biofilms
Peter Østrup Jensen,Alejandra Briales,Rikke Prejh Brochmann,Hengzhuang Wang,Kasper Nørskov Kragh,Mette Kolpen,Casper Hempel,Thomas Bjarnsholt,Niels Høiby,Oana Ciofu +9 more
TL;DR: It is shown that OH˙ is produced by P. aeruginosa biofilms treated with ciprofloxacin, which may contribute to the killing of biofilm subpopulations.
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Metallothionein-I+II in neuroprotection
Mie Østergaard Pedersen,Rikke Anker Jensen,Dan Sonne Pedersen,Dan Sonne Pedersen,Anders D. Skjolding,Casper Hempel,Casper Hempel,Lasse Maretty,Lasse Maretty,Milena Penkowa +9 more
TL;DR: The newest data on cerebral MT‐I+II functions following brain injury and experimental autoimmune encephalomyelitis are discussed, with a focus on the neuroprotective functions of the central nervous system.
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Bactericidal effect of colistin on planktonic Pseudomonas aeruginosa is independent of hydroxyl radical formation.
Rikke Prejh Brochmann,Anders Dyhr Toft,Oana Ciofu,Alejandra Briales,Mette Kolpen,Casper Hempel,Thomas Bjarnsholt,Niels Høiby,Peter Østrup Jensen +8 more
TL;DR: The bactericidal effect of colistin does not depend on the formation of toxic amounts of hydroxyl radicals (OH·) resulting from oxidative stress in metabolically active cells.
Journal ArticleDOI
Differential MicroRNA Expression in Experimental Cerebral and Noncerebral Malaria
Fatima El-Assaad,Casper Hempel,Casper Hempel,Valery Combes,Andrew J. Mitchell,Helen J. Ball,Jørgen A. L. Kurtzhals,Nicholas H. Hunt,Jean Marie Mathys,Georges E. Grau +9 more
TL;DR: The data suggest that in the CBA mouse at least, miRNA may have a regulatory role in the pathogenesis of severe malaria.