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Christian P. Hamel
Researcher at University of Montpellier
Publications - 224
Citations - 13304
Christian P. Hamel is an academic researcher from University of Montpellier. The author has contributed to research in topics: Retinitis pigmentosa & Retinal pigment epithelium. The author has an hindex of 51, co-authored 224 publications receiving 11890 citations. Previous affiliations of Christian P. Hamel include Centre national de la recherche scientifique & French Institute of Health and Medical Research.
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Journal ArticleDOI
Nuclear gene OPA1, encoding a mitochondrial dynamin-related protein, is mutated in dominant optic atrophy.
Cécile Delettre,Guy Lenaers,Jean-Michel Griffoin,Nadine Gigarel,Corinne Lorenzo,Pascale Belenguer,Laetitia Pelloquin,J. Grosgeorge,Claude Turc-Carel,Eric Perret,Catherine Astarie-Dequeker,Laetitia Lasquellec,B. Arnaud,Bernard Ducommun,Josseline Kaplan,Christian P. Hamel +15 more
TL;DR: A nuclear gene, OPA1, is described here a nuclear gene that maps within the candidate region and encodes a dynamin-related protein localized to mitochondria, demonstrating a role for mitochondria in retinal ganglion cell pathophysiology.
Journal ArticleDOI
Retinitis pigmentosa
TL;DR: The most common form of retinitis pigmentosa (RP) is a rod-cone dystrophy, in which the first symptom is night blindness, followed by the progressive loss in the peripheral visual field in daylight, and eventually leading to blindness after several decades.
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Mutations in RPE65 cause Leber's congenital amaurosis
Françoise Marlhens,C. Bareil,Jean-Michel Griffoin,Eberhart Zrenner,Amalric P,C. Eliaou,Shengfa Liu,Emily L. Harris,T M Redmond,B. Arnaud,Mireille Claustres,Christian P. Hamel +11 more
Journal ArticleDOI
The human dynamin-related protein OPA1 is anchored to the mitochondrial inner membrane facing the inter-membrane space.
Aurélien Olichon,Laurent J. Emorine,Eric Descoins,Laetitia Pelloquin,Laetitia Brichese,Nicole Gas,Emmanuelle Guillou,Cécile Delettre,Annie Valette,Christian P. Hamel,Bernard Ducommun,Guy Lenaers,Pascale Belenguer +12 more
TL;DR: Immuno‐fluorescence and biochemical evidences are presented showing that OPA1 resides in the mitochondria where it is imported through its highly basic amino‐terminal extension.
Journal ArticleDOI
Cone rod dystrophies
TL;DR: The clinical course of CRDs is generally more severe and rapid than that of RCDs, leading to earlier legal blindness and disability, and the visual prognosis is poor.