P
Pascale Belenguer
Researcher at University of Toulouse
Publications - 59
Citations - 6656
Pascale Belenguer is an academic researcher from University of Toulouse. The author has contributed to research in topics: Mitochondrion & mitochondrial fusion. The author has an hindex of 27, co-authored 58 publications receiving 6174 citations. Previous affiliations of Pascale Belenguer include Paul Sabatier University & Centre national de la recherche scientifique.
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Journal ArticleDOI
Nuclear gene OPA1, encoding a mitochondrial dynamin-related protein, is mutated in dominant optic atrophy.
Cécile Delettre,Guy Lenaers,Jean-Michel Griffoin,Nadine Gigarel,Corinne Lorenzo,Pascale Belenguer,Laetitia Pelloquin,J. Grosgeorge,Claude Turc-Carel,Eric Perret,Catherine Astarie-Dequeker,Laetitia Lasquellec,B. Arnaud,Bernard Ducommun,Josseline Kaplan,Christian P. Hamel +15 more
TL;DR: A nuclear gene, OPA1, is described here a nuclear gene that maps within the candidate region and encodes a dynamin-related protein localized to mitochondria, demonstrating a role for mitochondria in retinal ganglion cell pathophysiology.
Journal ArticleDOI
Loss of OPA1 perturbates the mitochondrial inner membrane structure and integrity, leading to cytochrome c release and apoptosis
Aurélien Olichon,Laurent Baricault,Nicole Gas,Emmanuelle Guillou,Annie Valette,Pascale Belenguer,Guy Lenaers +6 more
TL;DR: It is suggested that OPA1 is a major organizer of the mitochondrial inner membrane from which the maintenance of the cristae integrity depends and that abnormal apoptosis is a possible pathophysiological process leading to the retinal ganglion cells degeneration in ADOA patients.
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The human dynamin-related protein OPA1 is anchored to the mitochondrial inner membrane facing the inter-membrane space.
Aurélien Olichon,Laurent J. Emorine,Eric Descoins,Laetitia Pelloquin,Laetitia Brichese,Nicole Gas,Emmanuelle Guillou,Cécile Delettre,Annie Valette,Christian P. Hamel,Bernard Ducommun,Guy Lenaers,Pascale Belenguer +12 more
TL;DR: Immuno‐fluorescence and biochemical evidences are presented showing that OPA1 resides in the mitochondria where it is imported through its highly basic amino‐terminal extension.
Journal ArticleDOI
Mutation spectrum and splicing variants in the OPA1 gene.
Cécile Delettre,Jean-Michel Griffoin,Josseline Kaplan,Hélène Dollfus,Birgit Lorenz,Laurence Faivre,Guy Lenaers,Pascale Belenguer,Christian P. Hamel +8 more
TL;DR: It is hypothesize that at least two modifications of OPA1 may lead to dominant optic atrophy, that is alteration in GTPase activity and loss of the last seven C-terminal amino acids that putatively interact with other proteins.
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Mitochondrial fusion/fission dynamics in neurodegeneration and neuronal plasticity.
Ambre M. Bertholet,T. Delerue,A.M. Millet,M.F. Moulis,Claudine David,Marlène Daloyau,Laetitia Arnauné-Pelloquin,Noélie Davezac,Valérie Mils,Marie-Christine Miquel,Manuel Rojo,Manuel Rojo,Pascale Belenguer +12 more
TL;DR: The central actors of mitochondrial fusion and fission are presented and the role of mitochondrial dynamics in neuronal physiology and pathophysiology is reviewed and particular emphasis is placed on DRP1,MFN1-2, and OPA1 as well as on GDAP1, a protein of the mitochondrial outer membrane preferentially expressed in neurons.